Desmin is a cytoplasmic protein that is typically found in muscle cells, as well as their cancers. It is an intermediate filament and can be observed through electron microscopy.
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Mark R. Wick, Gene Philip Siegal (30 March 1988). Monoclonal Antibodies in Diagnostic Immunohistochemistry. CRC Press. ISBN 0824778383. Retrieved on 12 May 2012. “Desmin is a cytoplasmic protein that is characteristically found in muscle cells and their neoplasms [1-27]. It belongs to the class of "intermediate" (10 nm) filaments, which may be oberved in many cell types by electron microscopy [28-31]. In smooth muscle cells, these structures are associated with cytoplasmic dense bodies and subplasmalemmal dense plaques [29-31]; in striated muscle, they are linked to sarcomeric Z disks [28,32-25].”