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Hydrochlorofluorocarbon (HCFC): a compound consisting of hydrogen, chlorine, fluorine, and carbon.

The HCFCs are one class of chemicals being used to replace the CFCs. They contain chlorine and thus deplete stratospheric ozone, but to a much lesser extent than CFCs. HCFCs have ozone depletion potentials (ODPs) ranging from 0.01 to 0.1.

Production of HCFCs with the highest ODPs will be phased out first, followed by other HCFCs. A table of ozone-depleting substances shows their ODPs, GWPs, and CAS numbers. HCFCs are numbered according to a standard scheme.