Brison has won election to the Canadian House of Commons in five general elections:
- June 1997
- November 2000
- June 2004
- January 2006
- October 2008
He currently serves in the Official Opposition Shadow Cabinet as the Liberal Party Critic for Industry. In addition, he is co-chair of the Liberal Party of Canada Election Platform Committee with Bob Rae.
He served as Minister of Public Works and Government Services, and Receiver General of Canada, from 2004 to 2006.
He also served on three cabinet committees including:
- Treasury Board
- Domestic Affairs
- Expenditure Review
Brison previously served as Parliamentary Secretary to the Prime Minister with special emphasis on Canada-U.S. Relations. Lastly, he has served as Vice-Chairman and member of the House of Commons Standing Committee on Finance.
Brison is currently a member of the Canada-U.S. Inter-Parliamentary Group and has served as the vice-president of the Canadian group of the Inter-Parliamentary Union. In this role he has participated in Inter-Parliamentary Union conferences in Moscow and New York. He also served as a member of the Canadian delegation to two annual meetings of the European Bank for Reconstruction and Development in London.