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An organism's transcriptome is the entirety of its RNA.[1] After identifying 11,655 non-protein-coding RNAs in 2002, the FANTOM consortium concluded that the major component of the transcriptome is a Non-coding RNA.[2]

The Complexity of the Transcriptome

Molecular biologists originally believed that only one strand (the "sense" strand) of the DNA molecule contains information that is transcribed into RNA. The other, "antisense" strand, was expected to function only in DNA replication. However, ENCODE project and FANTOM consortium showed that this expectation has not come true and that RNAs are transcribed from both strands of DNA, while the "antisense" strand is a major component of transcriptome.[1]


  1. 1.0 1.1 Jonathan Wells (2011). The Myth of Junk DNA. Discovery Institute Press, 34. ISBN 978-1-9365990-0-4. 
  2. Miao-Chih Tsai et al. (6 August 2010). "Long Noncoding RNA as Modular Scaffold of Histone Modification Complexes". Science 329 (5992): 689–693. doi:10.1126/science.1192002. Retrieved 17 January 2015. 

See also