Few was born near Baltimore, Maryland, on June 8, 1748. His family moved to Orange County, North Carolina in 1758. With the exception of a brief period in the 1760's, Few was essentially self-educated. He found time to read and study law, and was admitted to the bar in 1776. , 
Few was one of the first men to enlist in the volunteer militia company formed in Hillsborough. He later enlisted in the Richmond County Regiment, which his brother commanded. After the fall of Savannah to the British, Few's regiment led continued resistance, eventually forcing the British to abandon Augusta. 
Following the war, Few won election to the Georgia Assembly, sat on the state's Executive Council, acted as state surveyor-general, and served as presiding judge of the Richmond County court. In 1780, he was appointed to represent Georgia in the Continental Congress. Though Few left Congress in 1782 to assist in rebuilding Georgia's government, he returned in 1786, and served through 1788.
While a member of that body, Few was asked by his state to serve concurrently in the Constitutional Convention that met in Philadelphia in 1787. This dual responsibility caused him to split his time between the two bodies and therefore to miss portions of the constitutional proceedings. Nevertheless, Few firmly supported the effort to create a strong national union and worked hard to secure the Continental Congress' approval of the new instrument of government. He also participated in the Georgia convention in 1788 that ratified the document.
Few was asked to represent Georgia at the Federal Constitutional Convention in 1787. Due to his responsibilities as a member of the Continental Congress, he was unable to attend all of the sessions, but nonetheless played an important role. He also participated in the Georgia convention in 1788 that ratified the document.
Later Political Service
In 1789, Few was elected to the United States Senate as one of Georgia's original Senators. He served through 1793, and was appointed a judge of the circuit court of Georgia in 1794--a position he held until 1797.
William Few died in Fishkill, New York on July 16, 1828. He was buried in Reformed Dutch Church Cemetery in Beacon, New York.