Chromosome
Template:StubA strand of DNA coiled around and supported by proteins.
History
By 1900 scientists knew that cells were the building blocks of living things. All living things start as a single fertilized cell which keeps dividing. Scientists identified tiny threads in the nucleus of the cells. Because they could stain the threads with colored dyes to study them under a microscope, they called the threads chromosomes, from the Greek words for colored bodies. They could see that chromosomes came in pairs, and that human cells all contained 23 matching pairs. American biologist Walter Sutton knew Mendel's principles of genetics work on peas, and suggested that chromosomes held the secret of inheritance.
Another American biologist, Thomas Hunt Morgan, developed the idea that chromosomes were made up of linked groups of factors called genes. He experimented with red-eyed fruit flies and found that sometimes a white-eyed fly appeared. When he mated them, he found that as he expected there were three red-eyed flies to every white-eyed fly, but that all the white-eyed flies were male. He concluded that the gene for white eyes must be on a chromosome that was related to being male. Later workers found that this is why some hereditary diseases such as hemophilia and muscular dystrophy only show in males, though women can carry the gene for the disease without showing it.
In 1991 a project called the Human Genome Project began to use computers to map the three billion base pairs which make up the 46 human chromosomes.