Linkage study - Revision history

WesleyS: link to de-orphan

2009-02-26T02:18:09Z

link to de-orphan

CPalmer: cat

2008-11-26T14:08:03Z

cat

Ed Poor: no intention of violating copyright - maybe I should email their webmaster for permission

2008-11-25T21:33:32Z

no intention of violating copyright - maybe I should email their webmaster for permission

Ed Poor: once again, not sure fair use applies here - but I'm not hiding it

2008-11-25T21:31:39Z

once again, not sure fair use applies here - but I'm not hiding it

Ed Poor: not sure this is fair use

2008-11-25T21:28:05Z

not sure this is fair use

New page

Study, linkage: A study aimed at establishing linkage between genes. Linkage is the tendency for genes and other genetic markers to be inherited together because of their location near one another on the same chromosome.

A gene is a functional physical unit of heredity that can be passed from parent to child. All genes in humans are pieces of DNA. Most genes contain information for making a specific protein.

The term "genetic marker" is broader than a gene. A genetic marker is simply a segment of DNA with an identifiable physical location on a chromosome whose inheritance can be followed. A genetic marker can have a function and thus be a gene. Or a marker can be a section of DNA with no known function.

Because DNA segments that lie near each other on a chromosome tend to be inherited together, markers are often used as tools for tracking the inheritance pattern of a gene that has not yet been identified but whose approximate location is known.

The statistical estimate of whether two loci are likely to lie near each other on a chromosome and are therefore likely to be inherited together is called a LOD score. A LOD score of 3 or more is generally taken to indicate that the two loci are linked and are close to one another.

Today linkage studies serve as ways of gene-hunting and genetic testing.

← Older revision		Revision as of 14:08, November 26, 2008
Line 12:		Line 12:

	The above was copied from http://www.medterms.com although the [[fair use]] rationale is a bit shaky.		The above was copied from http://www.medterms.com although the [[fair use]] rationale is a bit shaky.
		+	[[Category:Genetics]]

@@ Line 9: / Line 9: @@
 Today linkage studies serve as ways of gene-hunting and genetic testing.
 ----
 The above was copied from http://www.medterms.com although the [[fair use]] rationale is a bit shaky.

@@ Line 5: / Line 5: @@
 Because DNA segments that lie near each other on a chromosome tend to be inherited together, markers are often used as tools for tracking the inheritance pattern of a gene that has not yet been identified but whose approximate location is known.
-The statistical estimate of whether two loci are likely to lie near each other on a chromosome and are therefore likely to be inherited together is called a LOD score. A LOD score of 3 or more is generally taken to indicate that the two loci are linked and are close to one another.
+The statistical estimate of whether two loci are likely to lie near each other on a chromosome and are therefore likely to be inherited together is called a [[LOD score]]. A LOD score of 3 or more is generally taken to indicate that the two loci are linked and are close to one another.
 Today linkage studies serve as ways of gene-hunting and genetic testing.

@@ Line 1: / Line 1: @@
-Study, linkage: A study aimed at establishing linkage between genes. Linkage is the tendency for genes and other genetic markers to be inherited together because of their location near one another on the same chromosome.
+A '''linkage study''' aims at establishing linkage between [[gene]]s. Linkage is the tendency for genes and other [[genetic marker]]s to be inherited together because of their location near one another on the same [[chromosome]].
-A gene is a functional physical unit of heredity that can be passed from parent to child. All genes in humans are pieces of DNA. Most genes contain information for making a specific protein.
+A genetic marker is simply a segment of DNA with an identifiable physical location on a chromosome whose inheritance can be followed. A genetic marker can have a function and thus be a gene. Or a marker can be a section of DNA with no known function.
 Because DNA segments that lie near each other on a chromosome tend to be inherited together, markers are often used as tools for tracking the inheritance pattern of a gene that has not yet been identified but whose approximate location is known.
@@ Line 10: / Line 8: @@
 Today linkage studies serve as ways of gene-hunting and genetic testing.