Non-steroidal anti-inflammatory drug
Non-steroidal anti-inflammatory drugs (NSAIDs) are drugs that relieve inflammation, fever, and often have analgesic properties. The prominent groups of non-steroidal anti-inflammatory drugs are salicylates, including aspirin, Arylalkanoic acids, 2-Arylpropionic acids, including ibuprofen, N-Arylanthranilic acids, pyrazolidine derivatives, oxicams, and COX-2 Inhibitors.
The two primary adverse drug reactions of these drugs are irritation to the gastrointestinal tract and kidneys. In 1991 Daniel L. Simmons at Brigham Young University discovered COX-2 which was thought to be effective as an NSAID without gastrointestinal irritation, but little evidence of this exists.