'''Butler County''' is a county in the southeastern part of the state of [[Missouri]]. It was officially organized on February 27, 1849 and named for William O. Butler, a prominent general and politician. The county had a population of 42,794 at the 2010 census. Poplar Bluff is the county seat and largest city. | '''Butler County''' is a county in the southeastern part of the state of [[Missouri]]. It was officially organized on February 27, 1849 and named for William O. Butler, a prominent general and politician. The county had a population of 42,794 at the 2010 census. Poplar Bluff is the county seat and largest city. |