Cape Girardeau County, Missouri

Cape Girardeau County is a county in southeastern Missouri. It is the most populous county in that part of the state, with a population of 75,674 at the 2010 census. Jackson is the county seat, and Cape Girardeau, for which the county is named, is the largest city.

Cape Girardeau County is one of the five original counties in Missouri, having been organized in 1812 prior to statehood. Many of the neighboring counties in southeast Missouri were wholly or partially formed from its original territory.