Difference between revisions of "Scrapie"
Sievert 81 (talk | contribs) (Created page with "'''Scrapie''' is a transmissible spongiform encephalopathy in sheep and goats. It is caused by a prion from of PrP, known as PrPSc, although people debate the...") |
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| − | '''Scrapie''' is a [[transmissible spongiform encephalopathy]] in [[sheep]] and [[goat]]s. It is caused by a [[prion]] | + | '''Scrapie''' is a [[transmissible spongiform encephalopathy]] in [[sheep]] and [[goat]]s. It is caused by a [[prion]] form of PrP, known as PrPSc, although people debate the cause. Prions multiply by causing normally folded proteins of the same type to take on their abnormal shape, which then go on to do the same, in a kind of chain reaction. These abnormal proteins are gradually accumulated in the body, especially in nerve cells, which subsequently die. It is currently unknown (but very likely), if scrapie can cross the species barrier and infect humans. Scrapie infected sheep will scrape off their fur, which is the origin of the name. Scrapie usually affects sheep 3 to 5 years of age, due to its long incubation period. The primary mode of transmission is from mother to lamb through ingestion of placental or allantoic fluids. The condition is always fatal. Symptoms including repetitive scraping, ataxia, lesions, weight loss, anorexia, lethargy, and death. |
Revision as of 06:04, October 8, 2020
Scrapie is a transmissible spongiform encephalopathy in sheep and goats. It is caused by a prion form of PrP, known as PrPSc, although people debate the cause. Prions multiply by causing normally folded proteins of the same type to take on their abnormal shape, which then go on to do the same, in a kind of chain reaction. These abnormal proteins are gradually accumulated in the body, especially in nerve cells, which subsequently die. It is currently unknown (but very likely), if scrapie can cross the species barrier and infect humans. Scrapie infected sheep will scrape off their fur, which is the origin of the name. Scrapie usually affects sheep 3 to 5 years of age, due to its long incubation period. The primary mode of transmission is from mother to lamb through ingestion of placental or allantoic fluids. The condition is always fatal. Symptoms including repetitive scraping, ataxia, lesions, weight loss, anorexia, lethargy, and death.