Changes

*[[Smallpox]] (See also [[Edward Jenner]])

*[[Smallpox]] (See also [[Edward Jenner]])

===Influenza Vaccine===

===Influenza Vaccine===

The flu vaccine is an example of modern vaccination. Due to the change in [[allele]] frequency over time in the population of the influenza virus, new influenza vaccines are created each year.  In some years the vaccines are less effective than in other years. According to the CDC,"Influenza viruses are always changing. Therefore, influenza vaccines are updated every year, and annual vaccination is recommended".<ref> "Inactivated Influenza Vaccine, What you need to know," a publication of the Center for Disease Control, 2006. Available online at: https://www.cdc.gov/nip/publications/VIS/vis-flu.pdf</ref>

The [[flu]] vaccine is an example of modern vaccination. Due to the change in [[allele]] frequency over time in the population of the influenza virus, new influenza vaccines are created each year.  In some years the vaccines are less effective than in other years. According to the CDC,"Influenza viruses are always changing. Therefore, influenza vaccines are updated every year, and annual vaccination is recommended".<ref> "Inactivated Influenza Vaccine, What you need to know," a publication of the Center for Disease Control, 2006. Available online at: https://www.cdc.gov/nip/publications/VIS/vis-flu.pdf</ref>

Since the production of the vaccine must begin many months before the influenza season starts models of the population genetics of the virus must be produced.<ref>http://www.nature.com/nrd/journal/v5/n3/full/nrd1988.html Influenza vaccines</ref> The success of vaccinations programs is dependent on the accuracy of these predictions.<ref>http://www.nature.com/news/2003/030324/full/030324-5.html Flu changes modeled</ref> The National Institute of Health recently assigned $26 million to establish a research center to better develop molecular models of influenza.<ref>http://www.spiritindia.com/health-care-news-articles-8024.html $26 million NIH contract to establish new flu/bird flu Center of Excellence</ref>

Since the production of the vaccine must begin many months before the influenza season starts models of the population genetics of the virus must be produced.<ref>http://www.nature.com/nrd/journal/v5/n3/full/nrd1988.html Influenza vaccines</ref> The success of vaccinations programs is dependent on the accuracy of these predictions.<ref>http://www.nature.com/news/2003/030324/full/030324-5.html Flu changes modeled</ref> The National Institute of Health recently assigned $26 million to establish a research center to better develop molecular models of influenza.<ref>http://www.spiritindia.com/health-care-news-articles-8024.html $26 million NIH contract to establish new flu/bird flu Center of Excellence</ref>