*[[Abraham Attrep]], historian
*[[C. E. "Cap" Barham]], Ruston attorney, state senator from 1948 to 1952 and lieutenant governor from 1952 to 1956
*[[Clifton Ellis Byrd]], former one-year president of Louisiana Tech from 1906 to 1907; namesake of C. E. Byrd High School in Shreveport
*[[John Ardis Cawthon|Eleanor Albrecht Cawthon]], administrator in various capacities at Louisana Tech University
*[[John Ardis Cawthon]], educator and historian
*[[Claybrook Cottingham​]], tenth president of Louisiana Tech, 1941 to 1949
*[[C. C. Courtney]], radio announcer, songwriter, actor
*[[O.K. "Buddy" Davis]], sportswriter
*[[Paul M. Davis, Jr.]], orthopedic surgeon and real estate developer in Alexandria; born in Ruston
*[[Hollis Downs]], former state representative
*[[Clarence Faulk]], radio station owner, former publisher of the ''Ruston Daily Leader; his father was a founder of Delta Air Lines.
*[[Rick Gallot]], president of the University of Louisiana System, former president of Grambling State University, and a former Democrat state senator and state representative
*[[Ray Germany]], Louisiana Tech basketball All American, 1959-1960
*[[B. H. Gilley]], historian
*[[Dan Hollingsworth]], mayor from 1999 to 2015
*[[George B. Holstead]], attorney and state representative from 1964 to 1980
*[[Jerry Huckaby]], U.S. Representative from 1977 to 1993
*[[John S. Hunt]], Ruston native, Monroe attorney, Louisiana Public Service Commissioner from 1964 to 1972
*[[Fred W. Jones, Jr.]], judge of city, district, and appellate courts
*[[J. E. Keeny]], president of Louisiana Tech, 1908-1926; namesake of Keeny Hall
*[[K. D. Kilpatrick]], funeral home owner and one-term member of the Louisiana State Senate
*[[Ragan Madden]], state representatives in 1940; district attorney for Lincoln and Union parishes, 1949-1979
*[[C. Wade Meade]], historian
*[[Robert W. Mondy]], historian
*[[L. D. "Buddy" Napper]], attorney and state representative from 1952 to 1964 *[[Virgil Orr]], former Louisiana Tech administrator and former state representative*[[B. R. Patton]], former state senator for Lincoln and Union parishes
*[[Morgan D. Peoples]], historian
*[[Elton Pody]], mayor from 1983 to 1991
*[[E. S. Richardson]], president of Louisiana Tech from 1936 to 1941
*[[Norman Richardson]], journalist known for coverage of hurricanes, born in Ruston
*[[H. J. Sachs]], English professor
*[[Rob Shadoin]], state representative
*[[Don Shows]], national champion football coach originally from Ruston
*[[Robert C. Snyder]], professor and lecturer
*[[William Sumlin]], state representative, 1983-1988
*[[Lawson Swearingen]], former state senator reared in Ruston
*[[F. Jay Taylor]], former president of Louisiana Tech