Changes

A point mutation is the most limited type of mutation, whereby a single base nucleotide is replaced with another nucleotide.  Sometimes the expression "point mutation" can also include the addition or subtraction of a single base pair.

A '''point mutation''' is the most limited type of [[mutation]], whereby a single base [[nucleotide]] is replaced with another nucleotide.  Sometimes the expression "point mutation" can also include the addition or subtraction of a single base pair, which is also referred to as an "indel".

The sickle-cell disease has been described as a single point mutation in the beta hemoglobin gene, whereby a GAG codon is converted into GTG.  The GTG then mistakenly encodes the amino acid valine instead of glutamic acid.

The sickle-cell disease is caused by a single point mutation in one allele of the beta [[hemoglobin]] gene, whereby a CCT codon is converted into TCT.  The TCT then mistakenly encodes the [[amino acid]] serine instead of proline.

 

Point mutations do not add new information to the genome. <ref>Purdom, Georgia, [http://www.answersingenesis.org/articles/2008/02/01/feedback-new-information Feedback: Evidence of New Genetic Information?], 1st February, 2009 (Answers in Genesis)</ref>