| | The mainstay of treatment for leukemia is chemotherapy. Cytotoxic agents are introduced into the body which affect rapidly dividing cells, including cancer cells, resulting in their death. A patient will often undergo several cycles of chemotherapy, administered according to strict protocols. For example, AML is commonly treated with induction chemotherapy (under the 7:3 protocol), and then several cycles of consolidation chemotherapy (under the HiDAC protocol). Chemotherapy is often administered into the spinal cord and brain through intrathecal chemotherapy, particularly for ALL. | | The mainstay of treatment for leukemia is chemotherapy. Cytotoxic agents are introduced into the body which affect rapidly dividing cells, including cancer cells, resulting in their death. A patient will often undergo several cycles of chemotherapy, administered according to strict protocols. For example, AML is commonly treated with induction chemotherapy (under the 7:3 protocol), and then several cycles of consolidation chemotherapy (under the HiDAC protocol). Chemotherapy is often administered into the spinal cord and brain through intrathecal chemotherapy, particularly for ALL. |
| − | These affect rapidly dividing cells, including not only leukemia cells, but also normal blood cells, hair, and the mucosal surfaces lining the gastrointestinal tract. This produces a number of side effects, including a pancytopenia (high risk of infection and bleeding), nausea, vomitting, diarrhoea and hair loss. The mortality rate from chemotherapy is approximately 3-4%, the majority of these deaths due to infection. Patients are closely monitored following a cycle, and if they become febrile are treated with powerful IV antibiotics. | + | These affect rapidly dividing cells, including not only leukemia cells, but also normal blood cells, hair, and the mucosal surfaces lining the gastrointestinal tract. This produces a number of side effects, including a pancytopenia (high risk of infection and bleeding), nausea, vomiting, diarrhoea and hair loss. The mortality rate from chemotherapy is approximately 3-4%, the majority of these deaths due to infection. Patients are closely monitored following a cycle, and if they become febrile are treated with powerful IV antibiotics. |