Subtraction in binary can be carried out similar to decimal notation, however, there is a more efficient way, which is usually used in computers. Negative numbers a written in "Two's complement notation". In this notation, You "flip" the digits in the binary number and add one. For example, | Subtraction in binary can be carried out similar to decimal notation, however, there is a more efficient way, which is usually used in computers. Negative numbers a written in "Two's complement notation". In this notation, You "flip" the digits in the binary number and add one. For example, |