At high doses, MDMA may elevate heart rate and blood pressure significantly, cause dehydration, and hyperthermia. When used repeatedly on the order of several times a month, depression, persistent anxiety, and short-term memory loss may result. Whether or not these effects are reversible remains an area of ongoing research. | At high doses, MDMA may elevate heart rate and blood pressure significantly, cause dehydration, and hyperthermia. When used repeatedly on the order of several times a month, depression, persistent anxiety, and short-term memory loss may result. Whether or not these effects are reversible remains an area of ongoing research. |