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Induced pluripotent stem cells (view source)
Revision as of 21:16, September 9, 2018
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Since then, researchers have been focused on addressing the shortcomings of the original technique, notably its low efficiency<ref>e.g. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3448677/pdf/pone.0045633.pdf</ref> and the tumorigenicity <ref>e.g. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3204002/pdf/281_2011_Article_266.pdf</ref> of the resulting iPSCs, and many novel variations of the original method have been published. No current protocol for generating iPSCs is capable of producing cells that perfectly (and reliably) mimic the behavior of ES cells;<ref>http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3457607/pdf/CFG2012-538639.pdf</ref><ref>http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3114956/pdf/10815_2011_Article_9552.pdf</ref><ref>http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3159104/pdf/ars.2010.3814.pdf</ref> accordingly, techniques for generating iPSCs will remain an area of intense research for the foreseeable future.
Since then, researchers have been focused on addressing the shortcomings of the original technique, notably its low efficiency<ref>e.g. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3448677/pdf/pone.0045633.pdf</ref> and the tumorigenicity <ref>e.g. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3204002/pdf/281_2011_Article_266.pdf</ref> of the resulting iPSCs, and many novel variations of the original method have been published. No current protocol for generating iPSCs is capable of producing cells that perfectly (and reliably) mimic the behavior of ES cells;<ref>http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3457607/pdf/CFG2012-538639.pdf</ref><ref>http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3114956/pdf/10815_2011_Article_9552.pdf</ref><ref>http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3159104/pdf/ars.2010.3814.pdf</ref> accordingly, techniques for generating iPSCs will remain an area of intense research for the foreseeable future.
In 2012, Shinya Yamanaka was awarded the Nobel Prize in Medicine for his 2006 paper describing the production of iPSCs.<ref>http://www.washingtonpost.com/world/europe/2012-nobel-prize-announcements-being-with-medicine-award/2012/10/08/3f0284fe-110f-11e2-9a39-1f5a7f6fe945_story.html</ref>
In 2012, Shinya Yamanaka was awarded the Nobel Prize in Medicine for his 2006 paper describing the production of iPSCs.<ref>https://www.washingtonpost.com/world/europe/2012-nobel-prize-announcements-being-with-medicine-award/2012/10/08/3f0284fe-110f-11e2-9a39-1f5a7f6fe945_story.html</ref>
==Generation of iPSCs==
==Generation of iPSCs==