Because of its location, approximately halfway between [[St. Louis]] and [[Memphis]], and at the intersection of several major national highways, Sikeston is considered something of a gateway to the South. It is often included as part of the Missouri "Bootheel". | Because of its location, approximately halfway between [[St. Louis]] and [[Memphis]], and at the intersection of several major national highways, Sikeston is considered something of a gateway to the South. It is often included as part of the Missouri "Bootheel". |