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{{City
|picture =
|picture2 =
|map =
|country =United States
|state =Missouri
|region =
|settled =1860
|charter =
|population =16,318 (2010 census)
|area =17.48 mi²
|density =
|mayor =Steven Burch
|demonym =
|co-ordinates =
}}
'''Sikeston''' is a city in [[Scott County, Missouri|Scott]] and [[New Madrid County, Missouri|New Madrid]] Counties, [[Missouri]] (though mostly in Scott). Its population was 16,318 at the 2010 census, making it one of the largest cities in Southeast Missouri.
'''Sikeston''' is a city in [[Scott County, Missouri|Scott]] and [[New Madrid County, Missouri|New Madrid]] Counties, [[Missouri]] (though mostly in Scott). Its population was 16,318 at the 2010 census, making it one of the largest cities in Southeast Missouri.