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Talk:PNAS Response to Letter (view source)
Revision as of 23:39, September 16, 2008
, 23:39, September 16, 2008response to Aschlafly
:: Your refusal to concede point 2 is even more egregious. Lenski combined his experiments, and you can't claim that combination was simultaneously correct and incorrect. Moreover, the lack of scale also exists between Experiment 2 and 3, again disproving the underlying thesis of the paper.--[[User:Aschlafly|Aschlafly]] 18:31, 16 September 2008 (EDT)
:: Your refusal to concede point 2 is even more egregious. Lenski combined his experiments, and you can't claim that combination was simultaneously correct and incorrect. Moreover, the lack of scale also exists between Experiment 2 and 3, again disproving the underlying thesis of the paper.--[[User:Aschlafly|Aschlafly]] 18:31, 16 September 2008 (EDT)
:::I already said that I didn't think that we would reach common ground on points one, two, and four, and that it would be a waste of time to rehash them. You asked me to, so I did. It seems foolish to then treat those points as a shibboleth and refuse to discuss the other points, which I am fully prepared to concede provided you elaborate on why the Monte Carlo technique and the Z-transform were either the wrong tests or performed incorrectly. I am capable of accepting two items from a list of five even if I reject the other three. Even if I were completely incapable of agreeing with you, I still don't see why you won't put your best mathematical argument forward about the paper's statistics. Were there too few Monte Carlo resamplings? Do you feel that the Z-transformation was performed incorrectly? Is the Z-transform itself suspect? Do you propose some other statistical analysis? If you do, there are any number of us here who can crunch the numbers again. What a coup it would be for you if we could use a technique that you suggested to obtain results that smashed Lenski's smug complacency!
:::I don't claim that the combination was simultaneously correct and incorrect, by the way - I claim that it was correct. Where do I imply otherwise? Also, it's not only improper to compare replay one with replays two and three ''for scale'': it's impossible. Replay one involved constantly changing numbers of cells whereas replays two and three started with fixed numbers. How do you count the number of cells in the first replay to compare it to the other two? Is it the number of cells transferred each time? Is it the maximum population achieved in each flask prior to transfer? 750 generations passed in one case and 3700 generations in another before the Cit+ trait was seen - how do you factor that into the 'scale' equation? It is only the superficial resemblance of replays two and three that brings up the concept of 'scale'. The "underlying thesis" of the paper is not that there is a unique rate of mutation to Cit+ that applies across ''any and all'' experimental conditions.--[[User:Brossa|Brossa]] 19:39, 16 September 2008 (EDT)
== Please provide your statistical analysis ==
== Please provide your statistical analysis ==