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1) The breaching of the [[Weismann]] barrier, which dictates that there can be no soma to germline feedback
1) The breaching of the [[Weismann]] barrier, which dictates that there can be no soma to germline feedback
2) Insertional mutagenesis
2) Insertional mutagenesis
3) Validity of the DNA (i.e. requires several "bouts" of treatment)
3) Validity of the DNA (i.e. requires several "bouts" of treatment)
4) Viral vectors may regain ability to cause [[disease]]
4) Viral vectors may regain ability to cause [[disease]]