10. Lenski's paper claims that "During [30,000 generations], each population experienced billions of mutations,<ref>Lenski cites one of his own prior articles for this.</ref> far more than the number of possible point mutations in the [approximately] 4.6-million-bp genome. This ratio implies, to a first approximation, that each population tried every typical one-step mutation many times." Lenski's conclusion is nonsensical because it assumes that the mutations are completely random '''and''' that each mutation has a roughly equal probability. | 10. Lenski's paper claims that "During [30,000 generations], each population experienced billions of mutations,<ref>Lenski cites one of his own prior articles for this.</ref> far more than the number of possible point mutations in the [approximately] 4.6-million-bp genome. This ratio implies, to a first approximation, that each population tried every typical one-step mutation many times." Lenski's conclusion is nonsensical because it assumes that the mutations are completely random '''and''' that each mutation has a roughly equal probability. |