Ferdinand and Isabella
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Ferdinand and Isabella were the king and queen of Spain in the late A.D. 1400's, and specifically ruled over Castile and Aragon which later became the Kingdom of Spain. They were patrons of Christopher Columbus. After reconquering the Moorish Kingdom of Granada, they expelled the Jews and Muslims from Spain and established the Spanish Inquisition in part to prevent recapture of Spain by Muslims.
Their empire was inherited by their grandson, Holy Roman Emperor Charles V, who united the Spanish Empire with the Burgundian Inheritance and the Habsburg lands in Austria.