HIV (Human Immunodeficiency Virus) is an infectious human retrovirus that causes Acquired Immunodeficiency Syndrome (AIDS). HIV can be found in various body fluids, however its highest concentrations are found in semen, blood, and vaginal secretions. It can also be found in breast milk.
As summarized by the Centers for Disease Prevention and Control: "An exposure that might place HCP at risk for HIV infection is defined as a percutaneous injury (e.g., a needlestick or cut with a sharp object) or contact of mucous membrane or nonintact skin (e.g., exposed skin that is chapped, abraded, or afflicted with dermatitis) with blood, tissue, or other body fluids that are potentially infectious. In addition to blood and visibly bloody body fluids, semen and vaginal secretions also are considered potentially infectious. Although semen and vaginal secretions have been implicated in the sexual transmission of HIV, they have not been implicated in occupational transmission from patients to HCP. The following fluids also are considered potentially infectious: cerebrospinal fluid, synovial fluid, pleural fluid, peritoneal fluid, pericardial fluid, and amniotic fluid. The risk for transmission of HIV infection from these fluids is unknown; the potential risk to HCP from occupational exposures has not been assessed by epidemiologic studies in health-care settings. Feces, nasal secretions, saliva, sputum, sweat, tears, urine, and vomitus are not considered potentially infectious unless they are visibly bloody; the risk for transmission of HIV infection from these fluids and materials is low (7).
Any direct contact (i.e., contact without barrier protection) to concentrated virus in a research laboratory or production facility requires clinical evaluation. For human bites, clinical evaluation must include the possibility that both the person bitten and the person who inflicted the bite were exposed to bloodborne pathogens. Transmission of HIV infection by this route has been reported rarely, but not after an occupational exposure.
HIV is primarily spread by sexual contact and intravenous drug use. Most early infections in the US were via homosexual sex, most current infections in the world are via heterosexual contact and vertical transmission from mother to child. ch mothers infected with HIV transmit the virus to their baby in utero, or via breastfeeding.
- Contact with infected blood. This can include any physical contact with the blood of an infected person, including blood transfusions.
Other less likely means of transmission exist, though are rare. These include contact with the saliva, sweat or tears of an infected person.
References
Mandell, Bennett, & Dolin: Principles and Practice of Infectious Diseases, 6th ed., Copyright © 2005 Churchill Livingstone, An Imprint of Elsevier Guidelines for the Management of Occupational Exposures to HIV and Recommendations for Postexposure Prophylaxis. MMWR Recomm Rep. 2005;54:1-17.