Amedee was elected to the first of his senatorial terms in 2003 as a [[Democratic Party|Democrat]]. He led the six-candidate field with 12,413 votes (27.2 percent). The runner up was fellow Democrat Jeff Diez, who received 11,323 votes (24.8 percent). Two Republicans, Mark Stermer and Warren Harang, III, shared 30 percent of the vote. Two other Democrats held a combined 18 percent of the ballots.<ref name=elections>Louisiana Secretary of State, Election Returns, October 4, 2003.</ref> In the second balloting on November 15, Amedee defeated Diez, 24,190 (51.6 percent) to 22,668 (48.4 percent).<ref>Louisiana Secretary of State, Election Returns, November 15, 2003.</ref> Amedee was unopposed for his second term in the nonpartisan blanket [[primary]] held on October 20, 2007.
In March 2011, Amedee switched to [[Republican Party (United States)|GOP]] affiliation, and the Republicans gained numerical control of the state Senate.<ref name=vsmart/> He serves on the committees of (1) Environmental Quality, (2) Natural Resources as chairman, (3) Senate and Governmental Affairs, (4) Homeland Security, and (5) Veterans Affairs.<ref>{{cite web|url=http://senate.legis.state.la.us/amedee/assignments.asp|archive-url=https://archive.today/20120721000809/http://senate.legis.state.la.us/amedee/assignments.asp|url-status=dead|archive-date=July 21, 2012|title=Senator Jody Amedee - District 18|publisher=Louisiana State Senate|accessdate=August 31, 2011}}</ref> In 2010, Amedee supported the interest group, the Louisiana Association of Business and Industry 58 percent of the time. The [[conservative]] Louisiana Family Forum gave him an 80 percent rating. In 2009, he was ranked 100 percent by the Louisiana [[Right to Life]] Federation.<ref>{{cite web|url=httphttps://wwwjustfacts.votesmart.org/issue_rating_category.php?can_id=candidate/evaluations/35444/jody-amedee|title=Jody Amedee's Ratings and
Endorsements|publisher=Project Vote Smart|accessdate=April 2, 2020}}</ref>