Difference between revisions of "Polio"
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| + | Poliomyelitis, more commonly know as polio, is an infectious disease caused by an enterovirus of the same name. | ||
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| + | == Transmission == | ||
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| + | Polio, like most enteroviruses, is transmitted by the fecal-oral route, especially from ingestion of contaminated water. | ||
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| + | == Disease == | ||
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| + | Most cases (about 95%) of polio are asymptomatic, or cause minor respiratory or gastrointestinal symptoms. About 1 of every 1000 cases leads to paralytic polio. | ||
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| + | == Prevention == | ||
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| + | Previously widespread in the US, polio is now all but eradicated here. Until vaccines were developed in the 1950's, parents spent their summers in fear that their children would be struck down. Two basic types of vaccine were developed-- | ||
| + | :Oral Polio Vaccine (OPV)--this vaccine makes use of a live-attenuated form of the virus. It is administered orally, infects the host, and is spread in the same way as polio. It does not cause paralytic polio. One advantage of this vaccine is that it can "passively" vaccinate those who do not get vaccinated normally. Unfortunately, immunocompromised people can become quite ill from exposure, so this vaccine is largely being replaced in the US. | ||
| + | :Inactivated polio vaccine (IPV)--this is an injected vaccine that is now widely used in the US. | ||
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A common vaccine for Polio is IPOL, which is grown in cultures of Vero monkey kidney cells, according to Aventis Pasteur, its manufacturer. This poio innoculation has generally replaced the vaccine, Poliovax, manufactured by Sanofi Pasteur, which was produced from the cell line of an aborted fetal tissue, known as MRC-5. | A common vaccine for Polio is IPOL, which is grown in cultures of Vero monkey kidney cells, according to Aventis Pasteur, its manufacturer. This poio innoculation has generally replaced the vaccine, Poliovax, manufactured by Sanofi Pasteur, which was produced from the cell line of an aborted fetal tissue, known as MRC-5. | ||
Revision as of 20:15, March 17, 2007
Poliomyelitis, more commonly know as polio, is an infectious disease caused by an enterovirus of the same name.
Transmission
Polio, like most enteroviruses, is transmitted by the fecal-oral route, especially from ingestion of contaminated water.
Disease
Most cases (about 95%) of polio are asymptomatic, or cause minor respiratory or gastrointestinal symptoms. About 1 of every 1000 cases leads to paralytic polio.
Prevention
Previously widespread in the US, polio is now all but eradicated here. Until vaccines were developed in the 1950's, parents spent their summers in fear that their children would be struck down. Two basic types of vaccine were developed--
- Oral Polio Vaccine (OPV)--this vaccine makes use of a live-attenuated form of the virus. It is administered orally, infects the host, and is spread in the same way as polio. It does not cause paralytic polio. One advantage of this vaccine is that it can "passively" vaccinate those who do not get vaccinated normally. Unfortunately, immunocompromised people can become quite ill from exposure, so this vaccine is largely being replaced in the US.
- Inactivated polio vaccine (IPV)--this is an injected vaccine that is now widely used in the US.
A common vaccine for Polio is IPOL, which is grown in cultures of Vero monkey kidney cells, according to Aventis Pasteur, its manufacturer. This poio innoculation has generally replaced the vaccine, Poliovax, manufactured by Sanofi Pasteur, which was produced from the cell line of an aborted fetal tissue, known as MRC-5.
