The citric acid cycle is an ingenious series of reactions that oxidizes the acetyl group of acetyl-CoA to two molecules of CO2 in a manner that conserves the liberated free energy for utilization in ATP generation.
Reactions of the Cycle
Historical Perspective
Metabolic Sources of Acetyl-Coenzyme A
Pyruvate Dehydrogenase Multienzyme Complex
Control of Pyruvate Dehydrogenase
Enzymes of the Citric Acid Cycle
Citrate Synthase
Aconitase
NAD+-Dependent Isocitrate Dehydrogenase
α-Ketoglutarate Dehydrogenase
Succinyl-CoA Synthetase
Succinate Dehydrogenase
Fumarase
Malate Dehydrogenase
Integration of the Citric Acid Cycle
Regulation of the Citric Acid Cycle
The Amphibolic Nature of the Citric Acid Cycle