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'''Atherosclerosis''' is a disease process in which cholesterol accumulates in the walls of an artery. It is a chronic process, that gradually leads to stenosis, or narrowing, of the artery. The rupture of an atherosclerotic plaque can lead to the formation of a thrombus, which can occlude an artery, preventing the flow of blood. Depending on the location of the artery, this can lead to a variety of medical presentations.