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''The Compass of Pleasure'' examines the neurophysiology of the experience of pleasure, asking why people prferfer, and in some cases become addicted to, certain food, chemicals and behaviors. "There are variants in genes that turn down the function of dopamine signaling within the pleasure circuit," Linden explains. For people who carry these gene variants, their muted dopamine systems lead to blunted pleasure circuits, which in turn affects their pleasure-seeking activities.  People with blunted dopamine systems are driven to overindulge. Linden explains, "In order to get to that same set point of pleasure that others would get to easily — maybe with two drinks at the bar and a laugh with friends — you need six drinks at the bar to get the same thing."

''The Compass of Pleasure'' examines the neurophysiology of the experience of pleasure, asking why people prefer, and in some cases become addicted to, certain food, chemicals and behaviors. "There are variants in genes that turn down the function of dopamine signaling within the pleasure circuit," Linden explains. For people who carry these gene variants, their muted dopamine systems lead to blunted pleasure circuits, which in turn affects their pleasure-seeking activities.  People with blunted dopamine systems are driven to overindulge. Linden explains, "In order to get to that same set point of pleasure that others would get to easily — maybe with two drinks at the bar and a laugh with friends — you need six drinks at the bar to get the same thing."

"Any one of us could be an addict at any time," Linden says. "Addiction is not fundamentally a moral failing — it's not a disease of weak-willed losers. When you look at the biology, the only model of addiction that makes sense is a disease-based model, and the only attitude towards addicts that makes sense is one of compassion."<ref>http://www.npr.org/2011/06/23/137348338/compass-of-pleasure-why-some-things-feel-so-good</ref>

"Any one of us could be an addict at any time," Linden says. "Addiction is not fundamentally a moral failing — it's not a disease of weak-willed losers. When you look at the biology, the only model of addiction that makes sense is a disease-based model, and the only attitude towards addicts that makes sense is one of compassion."<ref>http://www.npr.org/2011/06/23/137348338/compass-of-pleasure-why-some-things-feel-so-good</ref>