Barbiturates dissolve easily in [[fat]]. Therefore, barbiturates have ready access to the brain because your brain is made of fat. Also, because barbiturates dissolve into body fat, they can accumulate and re-enter the [[blood]] stream later. Different barbiturates clear out of the blood stream at different rates. | Barbiturates dissolve easily in [[fat]]. Therefore, barbiturates have ready access to the brain because your brain is made of fat. Also, because barbiturates dissolve into body fat, they can accumulate and re-enter the [[blood]] stream later. Different barbiturates clear out of the blood stream at different rates. |