This is Article 1, Section 8, clause 3, and it is one of the most important clauses in all of the Constitution. In Federalist (Paper) No. 45, James Madison stated that that the Commerce Clause was “an addition which few oppose and from which no apprehensions are entertained.” | This is Article 1, Section 8, clause 3, and it is one of the most important clauses in all of the Constitution. In Federalist (Paper) No. 45, James Madison stated that that the Commerce Clause was “an addition which few oppose and from which no apprehensions are entertained.” |