At high doses, MDMA may elevate heart rate and blood pressure significantly, cause dehydration, and hyperthermia. When used repeatedly on the order of several times a month, depression, persistent anxiety, and short-term memory loss may result. Whether or not these effects are reversible remains an area of ongoing research. There is enough evidence to suggest that long term use of ecstasy at high doses can cause nerve damage in a number of users. Taking ecstasy during pregnancy can increase the risk of [[congenital trait|congenital abnormalities]] by a factor of 8. | At high doses, MDMA may elevate heart rate and blood pressure significantly, cause dehydration, and hyperthermia. When used repeatedly on the order of several times a month, depression, persistent anxiety, and short-term memory loss may result. Whether or not these effects are reversible remains an area of ongoing research. There is enough evidence to suggest that long term use of ecstasy at high doses can cause nerve damage in a number of users. Taking ecstasy during pregnancy can increase the risk of [[congenital trait|congenital abnormalities]] by a factor of 8. |