The discoveries of Koch and other great 19th century microbiologists stimulated the extension of Jenner's strategy of vaccination to other diseases. In the 1880's, [[Louis Pasteur]] devised a vaccine against cholera in chickens, and developed a rabies vaccine that proved a success upon its first trial use in a boy bitten by a rabid dog. These practical triumphs led to a search for the mechanism of protection and to the development of the science of immunology. In 1890, Emil von Behring and Shibasaburo Kitasato discovered that the serum of vaccinated individuals contained substances, which they called [[antibodies]], that specifically bound to the relevant pathogen. | The discoveries of Koch and other great 19th century microbiologists stimulated the extension of Jenner's strategy of vaccination to other diseases. In the 1880's, [[Louis Pasteur]] devised a vaccine against cholera in chickens, and developed a rabies vaccine that proved a success upon its first trial use in a boy bitten by a rabid dog. These practical triumphs led to a search for the mechanism of protection and to the development of the science of immunology. In 1890, Emil von Behring and Shibasaburo Kitasato discovered that the serum of vaccinated individuals contained substances, which they called [[antibodies]], that specifically bound to the relevant pathogen. |