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insifght
==Rosalind Franklin controversy==
==Rosalind Franklin controversy==
His personal and informal account of this discovery "The Double Helix" aroused some controversy with its frank account of the fiercely competitive nature of scientific research. In particular, he revealed that the crucial breakthrough was based on the work of [[Rosalind Franklin]], and her unpublished experimental results were used without her knowledge or permission. Franklin died before the Nobel Prize was awarded.
His personal and informal account of this discovery "The Double Helix" aroused some controversy with its frank account of the fiercely competitive nature of scientific research. In particular, he revealed that an important component of the breakthrough was the work of [[Rosalind Franklin]], and her unpublished experimental results were used without her knowledge or permission. Franklin died before the Nobel Prize was awarded.
==Final moment of great insight==
Watson and Crick worked in a office aggregating and integrating all the known knowledge that they could about what was then known about DNA chemistry. Watson had his great [[insight]] at their Cavendish office on February 28, 1953. He had constructed the flat cardboard models of the four base pairs. The base pairs consisted of purines adenine and guanine and the pyrimidines thymine and cytosine. He began trying different orientations of them, flipping them over and sliding them around on the office table. He saw a potential for hydrogen bonding between the adenine and thymine. He then oriented the guanine and cytosine in a similar way and saw the same hydrogen bonding pattern. He then compared the two aggregates and saw that they were similar in shape and he soon realized that they would be appropriate as perhaps rungs on a ladder and quickly became confident that he had made the final breakthrough.<ref>https://www.dnalc.org/view/15492-Discovering-the-double-helix-structure-of-DNA-James-Watson-video-with-3D-animation-and-narration.html</ref>
{{DEFAULTSORT:Watson,James}}
{{DEFAULTSORT:Watson,James}}
[[Category:Geneticists]]
[[Category:Geneticists]]
[[Category:Nobel laureates in Physiology or Medicine]]
[[Category:Nobel laureates in Physiology or Medicine]]