Changes

In the late 19th century [[Friedrich Miescher]], a Swiss [[biochemist]], discovered several different proteins and an unusual [[acid]] in the [[nucleus]] of cells. The acid was named deoxyribonucleic acid, or DNA. In 1944 two American [[biologist]]s, [[Alfred Hershey]] and [[Martha Chase]] used experiments with [[bacteria]] to show that DNA passed [[gene]]s from one generation to the next.  

In the late 19th century [[Friedrich Miescher]], a Swiss [[biochemist]], discovered several different proteins and an unusual [[acid]] in the [[nucleus]] of cells. The acid was named deoxyribonucleic acid, or DNA. In 1944 two American [[biologist]]s, [[Alfred Hershey]] and [[Martha Chase]] used experiments with [[bacteria]] to show that DNA passed [[gene]]s from one generation to the next.  

At that time, it was unclear how this simple molecule could hold all the complex information controlling the development of humans, animals and plants. Scientists knew it was made of four chemical bases called adenine (A), thymine (T), guanine (G) and cytosine (C), plus phosphoric acid and a sugar. They also knew that there was always the same amount of A as T and of G as C in cells, but they did not know the rules that controlled the arrangement.

At that time, it was unclear how this simple molecule could hold all the complex information controlling the development of humans, animals and plants. Scientists knew it was made of four chemical bases called [[adenine]] (A), [[thymine]] (T), [[guanine]] (G) and [[cytosine]] (C), plus [[phosphoric acid]] and a [[sugar]]. They also knew that there was always the same amount of A as T and of G as C in cells, but they did not know the rules that controlled the arrangement.

British scientists [[Rosalind Franklin]] and [[Maurice Wilkins]]  passed [[X-ray|X-rays]] through DNA to study the patterns made when the crystals diffracted them. From studying photographs of patterns, Rosalind Franklin concluded that DNA must be be a [[helix]]. [[James Watson]] and [[Francis Crick]], working in [[Cambridge]], used this information to help them solve the puzzle of DNA structure. They built a model showing that if A always paired with T and G paired with C, DNA must be like a ladder made of two strands twisted together in a double helix. The sugar and phosphoric acid were the sides of the ladder, and the rungs were the paired bases.

British scientists [[Rosalind Franklin]] and [[Maurice Wilkins]]  passed [[X-ray|X-rays]] through DNA to study the patterns made when the crystals diffracted them. From studying photographs of patterns, Rosalind Franklin concluded that DNA must be be a [[helix]]. [[James Watson]] and [[Francis Crick]], working in [[Cambridge]], used this information to help them solve the puzzle of DNA structure. They built a model showing that if A always paired with T and G paired with C, DNA must be like a ladder made of two strands twisted together in a double helix. The sugar and phosphoric acid were the sides of the ladder, and the rungs were the paired bases.