Changes

The American Amish have a low autism rate which may be due to their healthy and simple lifestyle, their genetic makeup or both.<ref>

The American Amish have a low autism rate which may be due to their healthy and simple lifestyle, their genetic makeup or both.<ref>

*[http://www.foxnews.com/health/2014/12/04/4-healthy-habits-to-steal-from-amish.html 4 healthy habits to steal from the Amish], Fox News Health, December 04, 2014

*[https://www.foxnews.com/health/2014/12/04/4-healthy-habits-to-steal-from-amish.html 4 healthy habits to steal from the Amish], Fox News Health, December 04, 2014

*"[http://www.internalmedicine.osu.edu/genetics/article.cfm?id=5307 Amish Have Lower Rates of Cancer, Ohio State Study Shows]". Columbus, OH: Ohio State University Medical Center. January 1, 2010. Retrieved January 6, 2010.

*"[http://www.internalmedicine.osu.edu/genetics/article.cfm?id=5307 Amish Have Lower Rates of Cancer, Ohio State Study Shows]". Columbus, OH: Ohio State University Medical Center. January 1, 2010. Retrieved January 6, 2010.

*Puffenberger, EG; Jinks, RN; Wang, H; Xin, B; Fiorentini, C; Sherman, EA; Degrazio, D; Shaw, C; Sougnez, C; Cibulskis, K; Gabriel, S; Kelley, RI; Morton, DH; Strauss, KA (Dec 2012). "A homozygous missense mutation in HERC2 associated with global developmental delay and autism spectrum disorder". Human Mutation 33 (12): 1639–1646

*Puffenberger, EG; Jinks, RN; Wang, H; Xin, B; Fiorentini, C; Sherman, EA; Degrazio, D; Shaw, C; Sougnez, C; Cibulskis, K; Gabriel, S; Kelley, RI; Morton, DH; Strauss, KA (Dec 2012). "A homozygous missense mutation in HERC2 associated with global developmental delay and autism spectrum disorder". Human Mutation 33 (12): 1639–1646

*Jackman, C; Horn, ND; Molleston, JP; Sokol, DK (Apr 2009). "Gene associated with seizures, autism, and hepatomegaly in an Amish girl". Pediatric Neurology 40 (4): 310–313.

*Jackman, C; Horn, ND; Molleston, JP; Sokol, DK (Apr 2009). "Gene associated with seizures, autism, and hepatomegaly in an Amish girl". Pediatric Neurology 40 (4): 310–313.

*Alarcón, Maricela; Abrahams, Brett S.; Stone, Jennifer L.; Duvall, Jacqueline A.; Perederiy, Julia V.; Bomar, Jamee M.; Sebat, Jonathan; Wigler, Michael; Martin, Christa L.; Ledbetter, David H.; Nelson, Stanley F.; Cantor, Rita M.; Geschwind, Daniel H. (10 January 2008). "Linkage, Association, and Gene-Expression Analyses Identify CNTNAP2 as an Autism-Susceptibility Gene". American Journal of Human Genetics 82 (1): 150–159</ref>  Due to their high levels of physical activity, the Amish have low rates of obesity.<ref>

*Alarcón, Maricela; Abrahams, Brett S.; Stone, Jennifer L.; Duvall, Jacqueline A.; Perederiy, Julia V.; Bomar, Jamee M.; Sebat, Jonathan; Wigler, Michael; Martin, Christa L.; Ledbetter, David H.; Nelson, Stanley F.; Cantor, Rita M.; Geschwind, Daniel H. (10 January 2008). "Linkage, Association, and Gene-Expression Analyses Identify CNTNAP2 as an Autism-Susceptibility Gene". American Journal of Human Genetics 82 (1): 150–159</ref>  Due to their high levels of physical activity, the Amish have low rates of obesity.<ref>

*[http://www.foxnews.com/health/2014/12/04/4-healthy-habits-to-steal-from-amish.html 4 healthy habits to steal from the Amish], Fox News Health, December 04, 2014</ref>   

*[https://www.foxnews.com/health/2014/12/04/4-healthy-habits-to-steal-from-amish.html 4 healthy habits to steal from the Amish], Fox News Health, December 04, 2014</ref>   

David N. Brown indicated: "In March 2006, Drs. Kevin Strauss, Holmes Morton and others documented 9 autistic Amish children, which could raise the autism rate of the Lancaster Amish community Olmsted supposedly investigated to almost 1/5,000 which is still a fraction of the US average of 1/68."<ref>Puffenberger, EG; Jinks, RN; Wang, H; Xin, B; Fiorentini, C; Sherman, EA; Degrazio, D; Shaw, C; Sougnez, C; Cibulskis, K; Gabriel, S; Kelley, RI; Morton, DH; Strauss, KA (Dec 2012). "A homozygous missense mutation in HERC2 associated with global developmental delay and autism spectrum disorder". Human Mutation 33 (12): 1639–1646</ref><ref>Jackman, C; Horn, ND; Molleston, JP; Sokol, DK (Apr 2009). "Gene associated with seizures, autism, and hepatomegaly in an Amish girl". Pediatric Neurology 40 (4): 310–313.</ref><ref>Alarcón, Maricela; Abrahams, Brett S.; Stone, Jennifer L.; Duvall, Jacqueline A.; Perederiy, Julia V.; Bomar, Jamee M.; Sebat, Jonathan; Wigler, Michael; Martin, Christa L.; Ledbetter, David H.; Nelson, Stanley F.; Cantor, Rita M.; Geschwind, Daniel H. (10 January 2008). "Linkage, Association, and Gene-Expression Analyses Identify CNTNAP2 as an Autism-Susceptibility Gene". American Journal of Human Genetics 82 (1): 150–159</ref>

David N. Brown indicated: "In March 2006, Drs. Kevin Strauss, Holmes Morton and others documented 9 autistic Amish children, which could raise the autism rate of the Lancaster Amish community Olmsted supposedly investigated to almost 1/5,000 which is still a fraction of the US average of 1/68."<ref>Puffenberger, EG; Jinks, RN; Wang, H; Xin, B; Fiorentini, C; Sherman, EA; Degrazio, D; Shaw, C; Sougnez, C; Cibulskis, K; Gabriel, S; Kelley, RI; Morton, DH; Strauss, KA (Dec 2012). "A homozygous missense mutation in HERC2 associated with global developmental delay and autism spectrum disorder". Human Mutation 33 (12): 1639–1646</ref><ref>Jackman, C; Horn, ND; Molleston, JP; Sokol, DK (Apr 2009). "Gene associated with seizures, autism, and hepatomegaly in an Amish girl". Pediatric Neurology 40 (4): 310–313.</ref><ref>Alarcón, Maricela; Abrahams, Brett S.; Stone, Jennifer L.; Duvall, Jacqueline A.; Perederiy, Julia V.; Bomar, Jamee M.; Sebat, Jonathan; Wigler, Michael; Martin, Christa L.; Ledbetter, David H.; Nelson, Stanley F.; Cantor, Rita M.; Geschwind, Daniel H. (10 January 2008). "Linkage, Association, and Gene-Expression Analyses Identify CNTNAP2 as an Autism-Susceptibility Gene". American Journal of Human Genetics 82 (1): 150–159</ref>

=== Genetics ===

=== Genetics ===

Some experts suspect that there is a genetic susceptibility to autism.<ref>http://healthland.time.com/2011/06/09/studies-new-clues-to-the-genetic-roots-of-autism/</ref><ref>http://www.foxnews.com/health/2011/08/11/autism-adhd-share-genetic-similarities/</ref><ref>http://www.latimes.com/health/la-he-autism-20110815,0,3154651.story</ref><ref>Happé F, Ronald A. The 'fractionable autism triad': a review of evidence from behavioural, genetic, cognitive and neural research. Neuropsychol Rev. 2008;18(4):287–304</ref><ref>Freitag CM. The genetics of autistic disorders and its clinical relevance: a review of the literature. Mol Psychiatry. 2007;12(1):2–22. doi:10.1038/sj.mp.4001896. PMID 17033636</ref> The genetics of this condition are not fully understood; perhaps caused by complex interactions between multiple genes which would account for the "spectrum" like differences in the severity of many cases <ref>http://66.102.1.104/scholar?hl=en&lr=&q=cache:7kMNqvTgRtoJ:www.ikhebeenvraag.be/mediastorage/FSDocument/52/Freitag-2.pdf+</ref><ref>http://www.ncbi.nlm.nih.gov/pubmed/17764594</ref>

Some experts suspect that there is a genetic susceptibility to autism.<ref>http://healthland.time.com/2011/06/09/studies-new-clues-to-the-genetic-roots-of-autism/</ref><ref>https://www.foxnews.com/health/2011/08/11/autism-adhd-share-genetic-similarities/</ref><ref>http://www.latimes.com/health/la-he-autism-20110815,0,3154651.story</ref><ref>Happé F, Ronald A. The 'fractionable autism triad': a review of evidence from behavioural, genetic, cognitive and neural research. Neuropsychol Rev. 2008;18(4):287–304</ref><ref>Freitag CM. The genetics of autistic disorders and its clinical relevance: a review of the literature. Mol Psychiatry. 2007;12(1):2–22. doi:10.1038/sj.mp.4001896. PMID 17033636</ref> The genetics of this condition are not fully understood; perhaps caused by complex interactions between multiple genes which would account for the "spectrum" like differences in the severity of many cases <ref>http://66.102.1.104/scholar?hl=en&lr=&q=cache:7kMNqvTgRtoJ:www.ikhebeenvraag.be/mediastorage/FSDocument/52/Freitag-2.pdf+</ref><ref>http://www.ncbi.nlm.nih.gov/pubmed/17764594</ref>

Simon Baron-Cohen, director of the Autism Research Centre at the [[University of Cambridge]] (U.K.) says that males and females are hardwired for different behavior, with boys tending to be stronger at mechanics, categorizing and systemizing information, mathematics, etc. and girls stronger at emotionalizing and empathizing.  He has proposed that autism is merely an extreme version of the [[male brain type]], in which the (female) urge to empathize is nearly absent and the brain is almost entirely hardwired for the (male) tasks of systemizing.<ref>Baron-Cohen, Simon.  ''The Essential Difference'', Basic Books 2003.</ref>

Simon Baron-Cohen, director of the Autism Research Centre at the [[University of Cambridge]] (U.K.) says that males and females are hardwired for different behavior, with boys tending to be stronger at mechanics, categorizing and systemizing information, mathematics, etc. and girls stronger at emotionalizing and empathizing.  He has proposed that autism is merely an extreme version of the [[male brain type]], in which the (female) urge to empathize is nearly absent and the brain is almost entirely hardwired for the (male) tasks of systemizing.<ref>Baron-Cohen, Simon.  ''The Essential Difference'', Basic Books 2003.</ref>