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Reverted edits by DanielMann (talk) to last revision by DavidB4-bot
[[Image:Vaccine.jpg|right|thumb|350px|[[Avian flu]] vaccine development]]
A '''vaccine''' is a pharmaceutical product containing an [[antigen]] designed to stimulate the production of antibodies against a particular disease or diseases.<ref>https://www.sciencenewsforstudents.org/article/explainer-what-vaccine</ref>
Many injuries from vaccination are admitted to by the government, and severe potential side effects are disclosed on packaging labels that most parents never see. The sharp rise in [[autism]], which is generally considered incurable and afflicts 1 out of every 59 children, has a correlation with the increase in vaccination; the incidence of autism appears to be greater in states where children receive more vaccines, such as [[New Jersey]] and [[North Carolina]].<ref>https://www.healthline.com/health/autism/autism-rates-by-state#2</ref> "The new estimate represents a 15% increase from two years prior and a 150% increase since 2000."<ref>https://www.cnn.com/2018/04/26/health/autism-prevalence-cdc/index.html</ref>
Traditionally a few highly tested vaccines were recommended for children to protect against deadly or severe diseases, such as [[smallpox]] and [[polio]]. Beginning in the 1990s, however, profit-driven vaccine manufacturers lobbied states and pediatrician organizations to compel numerous additional vaccines for sexually transmitted or less dangerous diseases. In addition, emotion based on inadequate information can cause over-vaccination.
17 US states have philosophical exemptions allowing parents to decline the vaccines; 47 states have religious exemptions; all states have medical exemptions,<ref>https://www.nvic.org/Vaccine-Laws/state-vaccine-requirements.aspx</ref><ref>http://www.vaccinesafety.edu/cc-exem.htm</ref> but they are hardest to obtain. Some parents choose to [[homeschooling|homeschool]] rather than submit their children to numerous vaccinations as required by state laws, due to lobbying by vaccine manufacturers, as a condition of being in school.
==Mechanism==
If the body produces an antibody against a particular disease or toxin it can identify the infection early on and the [[immune system]] can destroy it. Vaccines work by exposing the body to a form of the disease in such a way that it is much less likely cause illness but still allows antibodies to develop. This confers a level of immunity to the person or animal vaccinated.<ref>http://www.howstuffworks.com/immune-system7.htm How stuff works: Antibodies</ref>
Since the adoption of mass vaccination programs, many diseases have been curbed. [[Smallpox]], a contagious disease that killed 30 percent of those it infected, has been entirely eliminated through vaccination, excepting some strains maintained in labs for research purposes. Vaccination programs of the 19th and 20th century were effective at curbing the disease, and in 1979 the World Health Organization declared smallpox to be eradicated.<ref>https://www.cdc.gov/smallpox/history/history.html</ref>
Another disease that has been eliminated from the US is [[Polio]], which killed over 3,000 people in the United States in 1952,<ref>http://www.cdc.gov/nchs/data/vsus/VSUS_1952_2.pdf</ref> and afflicted such noted persons as President [[Franklin Delano Roosevelt]], actor Alan Alda, and musician Itzak Perlman. When doctors began using a vaccine to fight polio, it practically eradicated the disease in the developed world.<ref>https://www.cdc.gov/polio/progress/index.htm</ref>
The incidence of other diseases such as [[diphtheria]], [[pertussis]], and [[measles]], has decreased greatly from improvements in sanitation, increased awareness of the benefits of hand-washing and other preventive measures, and the invention of vaccines against these diseases.<ref>https://www.unicef.org/pon96/hevaccin.htm</ref>
While vaccines have been successful at preventing infectious disease, they have also resulted in controversy regarding their safety and effectiveness, legal and ethical issues surrounding mandatory vaccination, and whether children should be vaccinated against STDs<ref>https://www.historyofvaccines.org/content/articles/ethical-issues-and-vaccines</ref><ref>https://www.nvic.org/NVIC-Vaccine-News/January-2018/are-vaccine-ingredients-safe.aspx</ref>
If the body produces an antibody against a particular disease or toxin it can identify the infection early on and the [[immune system]] can destroy it. Vaccines work by exposing the body to a form of the disease in such a way that it is much less likely cause illness but still allows antibodies to develop. This confers a level of immunity to the person or animal vaccinated.<ref>http://www.howstuffworks.com/immune-system7.htm How stuff works: Antibodies</ref>
If the body produces an antibody against a particular disease or toxin it can identify the infection early on and the [[immune system]] can destroy it. Vaccines work by exposing the body to a form of the disease in such a way that it is much less likely cause illness but still allows antibodies to develop. This confers a level of immunity to the person or animal vaccinated.<ref>http://www.howstuffworks.com/immune-system7.htm How stuff works: Antibodies</ref>
There are five major types of vaccines and they are differentiated by what type of antigen is used. Live attenuated vaccines are created from the actual disease in question, however before injection the [[pathogen]] is [[attenuated]] (weakened) by growing successive generations of the pathogen in poor nutrient conditions. Because they contain live pathogens, it is still possible for these vaccines to cause infection, particularly in imunnocompromised individuals. Inactivated vaccines are created from pathogens that have been killed, usually with [[formaldehyde]]. Toxoid vaccines are created by using toxins produced by the pathogen, these toxins are exposed to heat and/or chemicals such as formaldehyde to inactivate the toxins, but [[antibodies]] that are produced to these deactivated toxins will also protect against the real toxin. Subunit vaccines use pieces of the pathogen in the vaccine. These pieces often consist of unique protein segments that stimulate the production of antibodies. Finally, conjugate vaccines protect against bacteria that are encapsulated in polysaccharides (complex sugars), which disguise the bacteria, making it hard for the immune system to recognize them. Conjugate vaccines overcome this by attaching the sugar to a protein the does stimulate the immune system, thus triggering the immune system to react to the sugar in the future even if it is not accompanied by the protein.<ref>https://www.cdc.gov/vaccines/hcp/conversations/downloads/vacsafe-understand-color-office.pdf</ref>
There are five major types of vaccines and they are differentiated by what type of antigen is used. Live attenuated vaccines are created from the actual disease in question, however before injection the [[pathogen]] is [[attenuated]] (weakened) by growing successive generations of the pathogen in poor nutrient conditions. Because they contain live pathogens, it is still possible for these vaccines to cause infection, particularly in imunnocompromised individuals. Inactivated vaccines are created from pathogens that have been killed, usually with [[formaldehyde]]. Toxoid vaccines are created by using toxins produced by the pathogen, these toxins are exposed to heat and/or chemicals such as formaldehyde to inactivate the toxins, but [[antibodies]] that are produced to these deactivated toxins will also protect against the real toxin. Subunit vaccines use pieces of the pathogen in the vaccine. These pieces often consist of unique protein segments that stimulate the production of antibodies. Finally, conjugate vaccines protect against bacteria that are encapsulated in polysaccharides (complex sugars), which disguise the bacteria, making it hard for the immune system to recognize them. Conjugate vaccines overcome this by attaching the sugar to a protein the does stimulate the immune system, thus triggering the immune system to react to the sugar in the future even if it is not accompanied by the protein.<ref>https://www.cdc.gov/vaccines/hcp/conversations/downloads/vacsafe-understand-color-office.pdf</ref>