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[[File:Autismbrain.jpg|thumbnail|200px|right|Autism affects the [[amygdala]], [[cerebellum]], and multiple other parts of the brain.]]

[[File:Autismbrain.jpg|thumbnail|200px|right|Autism affects the [[amygdala]], [[cerebellum]], and multiple other parts of the brain.]]

'''Autism''' is a type of pervasive developmental disorder. It is characterized by difficulties with social interaction; difficulties with verbal communication, especially pragmatic language; difficulty processing nonverbal communication such as facial expression; intense, narrow interests; difficulty adjusting to changes in routine; and repetitive behaviors. Other signs include lack of eye contact, delayed or unusual play skills, hypo- or hyper-sensitivity to sensory stimuli, and anxiety.<ref>http://www.webmd.com/brain/autism/development-disorder?page=2</ref> It is usually detected by the time a child is four years old but in some cases, autism goes unnoticed into adulthood. There are many intelligent and talented autistic individuals.<ref>Temple Grandin, "Thinking in Pictures, Expanded Edition: My Life with Autism" amazon link http://www.amazon.com/gp/product/0307275655/ref=wl_it_dp/103-3432247-4184629?ie=UTF8&coliid=I1CWNFSEUCIXQL&colid=49VN3HJC5OQK</ref>  The term '''autism''' was first used in 1912.  

'''Autism''' is a type of pervasive developmental disorder. It is characterized by difficulties with social interaction; difficulties with verbal communication, especially pragmatic language; difficulty processing nonverbal communication such as facial expression; intense, narrow interests; difficulty adjusting to changes in routine; and repetitive behaviors. Other signs include lack of eye contact, delayed or unusual play skills, hypo- or hyper-sensitivity to sensory stimuli, and anxiety.<ref>http://www.webmd.com/brain/autism/development-disorder?page=2</ref> It is usually detected by the time a child is four years old but in some cases, autism goes unnoticed into adulthood. There are many intelligent and talented autistic individuals.<ref>Temple Grandin, "Thinking in Pictures, Expanded Edition: My Life with Autism" amazon link https://www.amazon.com/gp/product/0307275655/ref=wl_it_dp/103-3432247-4184629?ie=UTF8&coliid=I1CWNFSEUCIXQL&colid=49VN3HJC5OQK</ref>  The term '''autism''' was first used in 1912.  

Diagnoses of autism has increased from 1:10,000 in 1988 to as high as 1 in 150 people,<ref>http://www.cdc.gov/ncbddd/autism/faq_prevalence.htm</ref> and it has been rising.  Four times as many boys suffer from autism as girls.<ref name="Clinic Stats">http://www.iupui.edu/~psycdept/autism/autism.htm</ref>  Among boys, 1 in 94 has the disorder.  In New Jersey, which has the highest rate in the nation, 1 in every 60 boys has autism and 1 in every 94 children is affected.  There is a seizure disorder in about one-third of those who have autism.<ref name="Clinic Stats"/>

Diagnoses of autism has increased from 1:10,000 in 1988 to as high as 1 in 150 people,<ref>https://www.cdc.gov/ncbddd/autism/faq_prevalence.htm</ref> and it has been rising.  Four times as many boys suffer from autism as girls.<ref name="Clinic Stats">http://www.iupui.edu/~psycdept/autism/autism.htm</ref>  Among boys, 1 in 94 has the disorder.  In New Jersey, which has the highest rate in the nation, 1 in every 60 boys has autism and 1 in every 94 children is affected.  There is a seizure disorder in about one-third of those who have autism.<ref name="Clinic Stats"/>

Autism is said to exist on a "spectrum;" that is, there is a wide range of how this disorder affects people. Other pervasive developmental disorders on the "autism spectrum" include [[Asperger's syndrome]], Pervasive Developmental Disorder - Not Otherwise Specified (PDD-NOS), Childhood Disintegrative Disorder, and Rett's Syndrome. There are many degrees of functioning in individuals with autism. Because of this, all individuals diagnosed with autism will not exhibit the same characteristics, or exhibit them to the same degree.  

Autism is said to exist on a "spectrum;" that is, there is a wide range of how this disorder affects people. Other pervasive developmental disorders on the "autism spectrum" include [[Asperger's syndrome]], Pervasive Developmental Disorder - Not Otherwise Specified (PDD-NOS), Childhood Disintegrative Disorder, and Rett's Syndrome. There are many degrees of functioning in individuals with autism. Because of this, all individuals diagnosed with autism will not exhibit the same characteristics, or exhibit them to the same degree.  

Although there have been no formal epidemiological studies, the evidence suggests that autism is rare in the economically developing continent of Africa and mainly exists within elite families.<ref name="Autism in Africa"/><ref>[http://www.ageofautism.com/2008/11/out-of-africa-a.html Out of Africa and Into Autism: More Evidence Illuminates the Somali Anomaly in Minnesota], By Mark F. Blaxill, AgeofAutism.com website (I don't agree with the anti-vaccine portion of the article)</ref> In addition, the traditional [[Africa]]n diet is healthier than many Western World invividuals' diets and Africa has some of the lowest obesity rates in the world.<ref>

Although there have been no formal epidemiological studies, the evidence suggests that autism is rare in the economically developing continent of Africa and mainly exists within elite families.<ref name="Autism in Africa"/><ref>[http://www.ageofautism.com/2008/11/out-of-africa-a.html Out of Africa and Into Autism: More Evidence Illuminates the Somali Anomaly in Minnesota], By Mark F. Blaxill, AgeofAutism.com website (I don't agree with the anti-vaccine portion of the article)</ref> In addition, the traditional [[Africa]]n diet is healthier than many Western World invividuals' diets and Africa has some of the lowest obesity rates in the world.<ref>

*[http://www.forbes.com/2007/02/07/worlds-fattest-countries-forbeslife-cx_ls_0208worldfat.html World's fattest countries]

*[https://www.forbes.com/2007/02/07/worlds-fattest-countries-forbeslife-cx_ls_0208worldfat.html World's fattest countries]

*[http://www.todaysdietitian.com/newarchives/030612p26.shtml Traditional African diets are healthier than Western diets], Today's Nutrition</ref>  Furthermore, Africa is a religious continent with high birth rates.

*[http://www.todaysdietitian.com/newarchives/030612p26.shtml Traditional African diets are healthier than Western diets], Today's Nutrition</ref>  Furthermore, Africa is a religious continent with high birth rates.

The American Amish have a low autism rate which may be due to their healthy and simple lifestyle, their genetic makeup or both.<ref>

The American Amish have a low autism rate which may be due to their healthy and simple lifestyle, their genetic makeup or both.<ref>

*[http://www.foxnews.com/health/2014/12/04/4-healthy-habits-to-steal-from-amish.html 4 healthy habits to steal from the Amish], Fox News Health, December 04, 2014

*[https://www.foxnews.com/health/2014/12/04/4-healthy-habits-to-steal-from-amish.html 4 healthy habits to steal from the Amish], Fox News Health, December 04, 2014

*"[http://www.internalmedicine.osu.edu/genetics/article.cfm?id=5307 Amish Have Lower Rates of Cancer, Ohio State Study Shows]". Columbus, OH: Ohio State University Medical Center. January 1, 2010. Retrieved January 6, 2010.

*"[http://www.internalmedicine.osu.edu/genetics/article.cfm?id=5307 Amish Have Lower Rates of Cancer, Ohio State Study Shows]". Columbus, OH: Ohio State University Medical Center. January 1, 2010. Retrieved January 6, 2010.

*Puffenberger, EG; Jinks, RN; Wang, H; Xin, B; Fiorentini, C; Sherman, EA; Degrazio, D; Shaw, C; Sougnez, C; Cibulskis, K; Gabriel, S; Kelley, RI; Morton, DH; Strauss, KA (Dec 2012). "A homozygous missense mutation in HERC2 associated with global developmental delay and autism spectrum disorder". Human Mutation 33 (12): 1639–1646

*Puffenberger, EG; Jinks, RN; Wang, H; Xin, B; Fiorentini, C; Sherman, EA; Degrazio, D; Shaw, C; Sougnez, C; Cibulskis, K; Gabriel, S; Kelley, RI; Morton, DH; Strauss, KA (Dec 2012). "A homozygous missense mutation in HERC2 associated with global developmental delay and autism spectrum disorder". Human Mutation 33 (12): 1639–1646

*Jackman, C; Horn, ND; Molleston, JP; Sokol, DK (Apr 2009). "Gene associated with seizures, autism, and hepatomegaly in an Amish girl". Pediatric Neurology 40 (4): 310–313.

*Jackman, C; Horn, ND; Molleston, JP; Sokol, DK (Apr 2009). "Gene associated with seizures, autism, and hepatomegaly in an Amish girl". Pediatric Neurology 40 (4): 310–313.

*Alarcón, Maricela; Abrahams, Brett S.; Stone, Jennifer L.; Duvall, Jacqueline A.; Perederiy, Julia V.; Bomar, Jamee M.; Sebat, Jonathan; Wigler, Michael; Martin, Christa L.; Ledbetter, David H.; Nelson, Stanley F.; Cantor, Rita M.; Geschwind, Daniel H. (10 January 2008). "Linkage, Association, and Gene-Expression Analyses Identify CNTNAP2 as an Autism-Susceptibility Gene". American Journal of Human Genetics 82 (1): 150–159</ref>  Due to their high levels of physical activity, the Amish have low rates of obesity.<ref>

*Alarcón, Maricela; Abrahams, Brett S.; Stone, Jennifer L.; Duvall, Jacqueline A.; Perederiy, Julia V.; Bomar, Jamee M.; Sebat, Jonathan; Wigler, Michael; Martin, Christa L.; Ledbetter, David H.; Nelson, Stanley F.; Cantor, Rita M.; Geschwind, Daniel H. (10 January 2008). "Linkage, Association, and Gene-Expression Analyses Identify CNTNAP2 as an Autism-Susceptibility Gene". American Journal of Human Genetics 82 (1): 150–159</ref>  Due to their high levels of physical activity, the Amish have low rates of obesity.<ref>

*[http://www.foxnews.com/health/2014/12/04/4-healthy-habits-to-steal-from-amish.html 4 healthy habits to steal from the Amish], Fox News Health, December 04, 2014</ref>   

*[https://www.foxnews.com/health/2014/12/04/4-healthy-habits-to-steal-from-amish.html 4 healthy habits to steal from the Amish], Fox News Health, December 04, 2014</ref>   

David N. Brown indicated: "In March 2006, Drs. Kevin Strauss, Holmes Morton and others documented 9 autistic Amish children, which could raise the autism rate of the Lancaster Amish community Olmsted supposedly investigated to almost 1/5,000 which is still a fraction of the US average of 1/68."<ref>Puffenberger, EG; Jinks, RN; Wang, H; Xin, B; Fiorentini, C; Sherman, EA; Degrazio, D; Shaw, C; Sougnez, C; Cibulskis, K; Gabriel, S; Kelley, RI; Morton, DH; Strauss, KA (Dec 2012). "A homozygous missense mutation in HERC2 associated with global developmental delay and autism spectrum disorder". Human Mutation 33 (12): 1639–1646</ref><ref>Jackman, C; Horn, ND; Molleston, JP; Sokol, DK (Apr 2009). "Gene associated with seizures, autism, and hepatomegaly in an Amish girl". Pediatric Neurology 40 (4): 310–313.</ref><ref>Alarcón, Maricela; Abrahams, Brett S.; Stone, Jennifer L.; Duvall, Jacqueline A.; Perederiy, Julia V.; Bomar, Jamee M.; Sebat, Jonathan; Wigler, Michael; Martin, Christa L.; Ledbetter, David H.; Nelson, Stanley F.; Cantor, Rita M.; Geschwind, Daniel H. (10 January 2008). "Linkage, Association, and Gene-Expression Analyses Identify CNTNAP2 as an Autism-Susceptibility Gene". American Journal of Human Genetics 82 (1): 150–159</ref>

David N. Brown indicated: "In March 2006, Drs. Kevin Strauss, Holmes Morton and others documented 9 autistic Amish children, which could raise the autism rate of the Lancaster Amish community Olmsted supposedly investigated to almost 1/5,000 which is still a fraction of the US average of 1/68."<ref>Puffenberger, EG; Jinks, RN; Wang, H; Xin, B; Fiorentini, C; Sherman, EA; Degrazio, D; Shaw, C; Sougnez, C; Cibulskis, K; Gabriel, S; Kelley, RI; Morton, DH; Strauss, KA (Dec 2012). "A homozygous missense mutation in HERC2 associated with global developmental delay and autism spectrum disorder". Human Mutation 33 (12): 1639–1646</ref><ref>Jackman, C; Horn, ND; Molleston, JP; Sokol, DK (Apr 2009). "Gene associated with seizures, autism, and hepatomegaly in an Amish girl". Pediatric Neurology 40 (4): 310–313.</ref><ref>Alarcón, Maricela; Abrahams, Brett S.; Stone, Jennifer L.; Duvall, Jacqueline A.; Perederiy, Julia V.; Bomar, Jamee M.; Sebat, Jonathan; Wigler, Michael; Martin, Christa L.; Ledbetter, David H.; Nelson, Stanley F.; Cantor, Rita M.; Geschwind, Daniel H. (10 January 2008). "Linkage, Association, and Gene-Expression Analyses Identify CNTNAP2 as an Autism-Susceptibility Gene". American Journal of Human Genetics 82 (1): 150–159</ref>

=== Genetics ===

=== Genetics ===

Some experts suspect that there is a genetic susceptibility to autism.<ref>http://healthland.time.com/2011/06/09/studies-new-clues-to-the-genetic-roots-of-autism/</ref><ref>http://www.foxnews.com/health/2011/08/11/autism-adhd-share-genetic-similarities/</ref><ref>http://www.latimes.com/health/la-he-autism-20110815,0,3154651.story</ref><ref>Happé F, Ronald A. The 'fractionable autism triad': a review of evidence from behavioural, genetic, cognitive and neural research. Neuropsychol Rev. 2008;18(4):287–304</ref><ref>Freitag CM. The genetics of autistic disorders and its clinical relevance: a review of the literature. Mol Psychiatry. 2007;12(1):2–22. doi:10.1038/sj.mp.4001896. PMID 17033636</ref> The genetics of this condition are not fully understood; perhaps caused by complex interactions between multiple genes which would account for the "spectrum" like differences in the severity of many cases <ref>http://66.102.1.104/scholar?hl=en&lr=&q=cache:7kMNqvTgRtoJ:www.ikhebeenvraag.be/mediastorage/FSDocument/52/Freitag-2.pdf+</ref><ref>http://www.ncbi.nlm.nih.gov/pubmed/17764594</ref>

Some experts suspect that there is a genetic susceptibility to autism.<ref>http://healthland.time.com/2011/06/09/studies-new-clues-to-the-genetic-roots-of-autism/</ref><ref>https://www.foxnews.com/health/2011/08/11/autism-adhd-share-genetic-similarities/</ref><ref>https://www.latimes.com/health/la-he-autism-20110815,0,3154651.story</ref><ref>Happé F, Ronald A. The 'fractionable autism triad': a review of evidence from behavioural, genetic, cognitive and neural research. Neuropsychol Rev. 2008;18(4):287–304</ref><ref>Freitag CM. The genetics of autistic disorders and its clinical relevance: a review of the literature. Mol Psychiatry. 2007;12(1):2–22. doi:10.1038/sj.mp.4001896. PMID 17033636</ref> The genetics of this condition are not fully understood; perhaps caused by complex interactions between multiple genes which would account for the "spectrum" like differences in the severity of many cases <ref>http://66.102.1.104/scholar?hl=en&lr=&q=cache:7kMNqvTgRtoJ:www.ikhebeenvraag.be/mediastorage/FSDocument/52/Freitag-2.pdf+</ref><ref>https://www.ncbi.nlm.nih.gov/pubmed/17764594</ref>

Simon Baron-Cohen, director of the Autism Research Centre at the [[University of Cambridge]] (U.K.) says that males and females are hardwired for different behavior, with boys tending to be stronger at mechanics, categorizing and systemizing information, mathematics, etc. and girls stronger at emotionalizing and empathizing.  He has proposed that autism is merely an extreme version of the [[male brain type]], in which the (female) urge to empathize is nearly absent and the brain is almost entirely hardwired for the (male) tasks of systemizing.<ref>Baron-Cohen, Simon.  ''The Essential Difference'', Basic Books 2003.</ref>

Simon Baron-Cohen, director of the Autism Research Centre at the [[University of Cambridge]] (U.K.) says that males and females are hardwired for different behavior, with boys tending to be stronger at mechanics, categorizing and systemizing information, mathematics, etc. and girls stronger at emotionalizing and empathizing.  He has proposed that autism is merely an extreme version of the [[male brain type]], in which the (female) urge to empathize is nearly absent and the brain is almost entirely hardwired for the (male) tasks of systemizing.<ref>Baron-Cohen, Simon.  ''The Essential Difference'', Basic Books 2003.</ref>