Several major highways run through the county. These include Interstate 55, paralleled a few miles to the west by the older U.S. Route 61, both of which run from north to south through the center of the county; U.S. Route 60, which runs along its southern edge; and Interstate 57, which along with U.S. Route 62 cuts through Sikeston and the southeastern corner. | Several major highways run through the county. These include Interstate 55, paralleled a few miles to the west by the older U.S. Route 61, both of which run from north to south through the center of the county; U.S. Route 60, which runs along its southern edge; and Interstate 57, which along with U.S. Route 62 cuts through Sikeston and the southeastern corner. |