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'''Sikeston''' is a city in [[Scott County, Missouri|Scott]] and New Madrid Counties, [[Missouri]] (though mostly in Scott). Its population was 16,318 at the 2010 census, making it one of the largest cities in Southeast Missouri.
Because of its location, approximately halfway between [[St. Louis]] and [[Memphis]], and at the intersection of several major national highways, Sikeston is considered something of a gateway to the South. It is often included as part of the Missouri "Bootheel".