The three major highways in the county are Interstate 55, which passes from northwest to southeast on a line skirting the western edge of Perryville; U.S. Route 61, which passes through the center of Perryville but otherwise generally parallels the interstate several miles to the east; and Missouri State Highway 51, which enters the county from the southwest, intersects I-55 and U.S. 61 at Perryville, and continues north to the Mississippi River, where it crosses the Chester Bridge into Illinois. | The three major highways in the county are Interstate 55, which passes from northwest to southeast on a line skirting the western edge of Perryville; U.S. Route 61, which passes through the center of Perryville but otherwise generally parallels the interstate several miles to the east; and Missouri State Highway 51, which enters the county from the southwest, intersects I-55 and U.S. 61 at Perryville, and continues north to the Mississippi River, where it crosses the Chester Bridge into Illinois. |