Changes

In October, 2013, Shi and her team published a paper in ''Nature''.  They claimed a breakthrough in coronavirus research.  They successfully isolated three viruses from bats, one of which had a S Protein that integrated with human ACE-2 receptors.  This effectively demonstrated the direct human infection of SARS-like viruses to humans, without the need of an intermediate host.

In October, 2013, Shi and her team published a paper in ''Nature''.  They claimed a breakthrough in coronavirus research.  They successfully isolated three viruses from bats, one of which had a S Protein that integrated with human ACE-2 receptors.  This effectively demonstrated the direct human infection of SARS-like viruses to humans, without the need of an intermediate host.

Then in November, 2015, Shi and her team at the Wuhan virology lab once again published a paper.  This time in the British journal, ''Nature Medicine''.  They discussed the creation of a synthetic virus, a self-replicating Chimeric virus.  This virus had the SARS virus as the framework, with the key S protein replaced, by the one they had found in a bat coronavirus, she mentioned in her 2013 paper.  This new virus demonstrated a powerful ability for cross-species infection.

Then in November, 2015, Shi and her team at the Wuhan virology lab once again published a paper.  This time in the British journal, ''Nature Medicine''.<ref>https://www.nature.com/articles/nm.3985</ref> They discussed the creation of a synthetic virus, a self-replicating Chimeric virus.  This virus had the SARS virus as the framework, with the key S protein replaced, by the one they had found in a bat coronavirus, she mentioned in her 2013 paper.  This new virus demonstrated a powerful ability for cross-species infection.

The mice infected with the synthetic virus revealed severe lung damage with no cure.  This symbolized that Shi's successful splicing of the SARS virus, was a key to open the door to the cross-species transmission.  They planned to further experiment on [[primate]]s, although Shi Zhengli did not indicate any conclusion from this research.  Her move to research on primates wasn't done without controversy.  Shi's experiments quickly triggered widespread debates from the academic community.  Simon Wain-Hobson of the Pasteur Institute in [[France]], expressed deep concerns. He told ''Nature'', "If the new virus escaped, nobody could predict the trajectory.  Propagation could happen anywhere."<ref>https://www.the-scientist.com/news-opinion/lab-made-coronavirus-triggers-debate-34502</ref>

The mice infected with the synthetic virus revealed severe lung damage with no cure.  This symbolized that Shi's successful splicing of the SARS virus, was a key to open the door to the cross-species transmission.  They planned to further experiment on [[primate]]s, although Shi Zhengli did not indicate any conclusion from this research.  Her move to research on primates wasn't done without controversy.  Shi's experiments quickly triggered widespread debates from the academic community.  Simon Wain-Hobson of the Pasteur Institute in [[France]], expressed deep concerns. He told ''Nature'', "If the new virus escaped, nobody could predict the trajectory.  Propagation could happen anywhere."<ref>https://www.the-scientist.com/news-opinion/lab-made-coronavirus-triggers-debate-34502</ref>