7
edits
Changes
Jump to navigation
Jump to search
mLine 31:
Line 31: − + − + + + + + + + + +
added info
Hinokitiol has shown an established mechanism to antagonize epidermal growth factor receptor (EGFR) protein expression in mammosphere production breast cancer stem/progenitor cells (BCSCs) without altering the messenger RNA expression. Hinokitiol also decreased the stability of EGFR in BCSCs. The stable protein expression of EGFR and vasculogenic mimicry (VM) production capability of hinokitiol treated BCSCs were restored by combination treatment with a proteasome antagonist, MG132. It can be concluded that hinokitiol may antagonize the VM activity of BCSCs by stimulating proteasome-mediated EGFR break-down. Hinokitiol may be considered as a novel breast cancer therapeutic agent, by acting as an anti-VM. [https://www.spandidos-publications.com/10.3892/ol.2016.4300#:~:text=Hinokitiol%20dose%2Ddependently%20inhibits%20VM,anti%2Dinflammatory%20and%20antitumor%20activity [20<nowiki>]</nowiki>]
Hinokitiol has shown an established mechanism to antagonize epidermal growth factor receptor (EGFR) protein expression in mammosphere production breast cancer stem/progenitor cells (BCSCs) without altering the messenger RNA expression. Hinokitiol also decreased the stability of EGFR in BCSCs. The stable protein expression of EGFR and vasculogenic mimicry (VM) production capability of hinokitiol treated BCSCs were restored by combination treatment with a proteasome antagonist, MG132. It can be concluded that hinokitiol may antagonize the VM activity of BCSCs by stimulating proteasome-mediated EGFR break-down. Hinokitiol may be considered as a novel breast cancer therapeutic agent, by acting as an anti-VM. [https://www.spandidos-publications.com/10.3892/ol.2016.4300#:~:text=Hinokitiol%20dose%2Ddependently%20inhibits%20VM,anti%2Dinflammatory%20and%20antitumor%20activity [20<nowiki>]</nowiki>]
Further study demonstrated Hinokitiol regulates estrogen receptor signaling and also antagonize the proliferation breast cancer cells in humans. Hence, it can be considered as a promising agent against the treatment of hormone sensitive mammary tumorigenesis.[https://www.tandfonline.com/doi/full/10.1080/09168451.2015.1008978 [21<nowiki>]</nowiki>]
Further study demonstrated Hinokitiol regulates estrogen receptor signaling and also antagonizes the proliferation of breast cancer cells in humans. Hence, it can be considered as a promising agent against the treatment of hormone-sensitive mammary tumorigenesis.[https://www.tandfonline.com/doi/full/10.1080/09168451.2015.1008978 [21<nowiki>]</nowiki>]
'''Hinokitiol with Curcumin'''
'''Hinokitiol with Curcumin'''
A potent effect was observed against NSCLC and gefitinib resistant NSCLC cells, when Hinokitiol was used in combination with Curcumin. This treatment indicated minimal cytotoxicity to healthy cells. [https://journals.sagepub.com/doi/10.1177/1934578X1801301223 [22<nowiki>]</nowiki>]
A potent effect was observed against NSCLC and gefitinib resistant NSCLC cells when Hinokitiol was used in combination with Curcumin. This treatment indicated minimal cytotoxicity to healthy cells. [https://journals.sagepub.com/doi/10.1177/1934578X1801301223 [22<nowiki>]</nowiki>]
'''Coronavirus research'''
Potential antiviral effects of Hinokitiol arise from its action as a zinc ionophore. Hinokitiol enables the influx of zinc ions into cells, which inhibit the replication machinery of RNA viruses, and subsequently hindering the replication of the virus.[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2612303/ [23<nowiki>]</nowiki>] Some notable RNA viruses include the human influenza virus, SARS. Zinc ions were able to inhibit viral replication within cells significantly and proved that the action was dependent on zinc influx. This study was done with the zinc ionophore pyrithione, which functions very similarly to Hinokitiol.[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2973827/ [24<nowiki>]</nowiki>] In cell cultures, hinokitiol inhibit human rhinovirus, coxsackievirus, and mengovirus multiplication. Hinokitiol interferes with the processing of viral polyproteins, thus inhibiting picornavirus replication. Hinokitiol inhibits the replication of picornaviruses by impairing the viral polyprotein processing and that the antiviral activity of hinokitiol is dependent on the availability of zinc ions.[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2612303/ [25<nowiki>]</nowiki>]
'''Iron ionophore'''
Hinokitiol has been shown to restore hemoglobin production in rodents. Hinokitiol acts as an iron ionophore to channel iron into cells,[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5470741/ [26<nowiki>]</nowiki>][https://www.sciencemag.org/news/2017/05/iron-man-molecule-restores-balance-cells [27<nowiki>]</nowiki>] increasing intracellular iron levels. Approximately 70% of the iron in humans is contained within red blood cells and specifically the hemoglobin protein. Iron is essential to almost all living organisms, and it is a critical element of several anatomical functions such as the oxygen transport system, deoxyribonucleic acid (DNA) synthesis, and electron transport and an iron deficiency can lead to blood disorders such as Anemia which, can be significantly detrimental to both physical and mental performance.[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3999603 [28<nowiki>]</nowiki>]