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Hinokitiol is a Zinc ionophore, and this capability is believed to inhibit viral replication. In brief, as a zinc ionophore, Hinokitiol aids in the transport molecules into cells through a plasma membrane or intracellular membrane, thus increasing the intracellular concentration of the specified molecule (ex. Zinc). Hence, by taking advantage of Zinc’s antiviral properties, in combination with Hinokitiol, Zinc uptake can be accelerated.[https://www.sciencedirect.com/topics/neuroscience/ionophores]

[[Hinokitiol]] is one of the [[Zinc Ionophores]], which means they can attach themselves to Zinc molecules and transport them across the cell membranes hence increasing the intracellular zinc concentrations; therefore many studies revealed this capability has the potential to inhibit viral replication. The advantage of Zinc’s antiviral properties can be accelerated by using it in combination with Hinokitiol.[https://www.sciencedirect.com/topics/neuroscience/ionophores]

 

 

According to a recent article on Nutritional Immunology, Zinc ionophore such as hinokitiol hindered the RNA synthesis by inhibiting the RNA dependent polymerase in picornavirus, poliovirus, and influenza. [https://www.frontiersin.org/articles/10.3389/fimmu.2020.01712/full [2<nowiki>]</nowiki>]