Changes

==HCQ and Covid 19==

==HCQ and Covid 19==

Prior to 2020, chloroquine (hydroxychloroquine's close cousin) was shown to be effective against SARS-CoV, a pathogen that is related to SARS-CoV-2.  A study published on August 22, 2005 in the ''Virology Journal'', almost 15 years before COVID-19 concluded [https://virologyj.biomedcentral.com/articles/10.1186/1743-422X-2-69 Chloroquine is a potent inhibitor of SARS coronavirus infection and spread.]<ref>[https://virologyj.biomedcentral.com/articles/10.1186/1743-422X-2-69 Chloroquine is a potent inhibitor of SARS coronavirus infection and spread] by Martin J Vincent (22 August 2005) ''Virology Journal''</ref>  Other journal articles which suggested chloroquine could be effective against coronavirus were ''Effects of chloroquine on viral infections: an old drug against today's diseases?'' (2003), ''In vitro inhibition of severe acute respiratory syndrome coronavirus by chloroquine'' (2004), and ''New insights into the antiviral effects of chloroquine'' (2006).<ref name=c19study>[https://c19study.com/  C19 Study] by CovidAnalysis (accessed 31 July 2020)</ref>  Doctors familiar with medical research began prescribing hydroxychloroquine to combat SARS-CoV-2 because it was a less toxic alternative to chloroquine, and the aforementioned studies meant that both drugs were treatment options worthy of serious consideration.  Two of the first countries to use HCQ were South Korea, who used hydroxychloroquine + zinc, and France, who used hydroxychloroquine + azithromycin. In the case of the USA, HCQ achieved prominence when [[Donald Trump]] promoted the drug as a treatment for COVID-19.  This view was inline with some of his political advisers such as [[Rudy Giuliani]], but certainly not all, Dr. Anthony Fauci being the principal skeptic.  In the case of [[Rudy Giuliani]], he conducted an interview with Dr. Vladimir Zelenko on his podcast ''Common Sense'' where Dr. Zelenko promoted the three drug regiment he was using to treat patients in New York - hydroxychloroquine (HCQ) + zinc + azithromycin (AZ).  This was a combination of the South Korean and French approaches to treating the disease.  Zelenko concluded that his treatment protocol was being effective based off of the results he was having treating his patients.<ref name=Zelenko1>[https://www.youtube.com/watch?v=1TJdjhd_XG8 EXCELLENT NEWS: Hydroxychloroquine Treatment Effective on 699 Patients] by Rudy Guiliani (Mar 28, 2020) ''Common Sense''</ref>   

Prior to 2020, chloroquine (hydroxychloroquine's close cousin) was shown to be effective against SARS-CoV, a pathogen that is related to SARS-CoV-2.  A study published on August 22, 2005 in the ''Virology Journal'', almost 15 years before COVID-19 concluded [https://virologyj.biomedcentral.com/articles/10.1186/1743-422X-2-69 Chloroquine is a potent inhibitor of SARS coronavirus infection and spread.]<ref>[https://virologyj.biomedcentral.com/articles/10.1186/1743-422X-2-69 Chloroquine is a potent inhibitor of SARS coronavirus infection and spread] by Martin J Vincent (22 August 2005) ''Virology Journal''</ref>  Other journal articles which suggested chloroquine could be effective against coronavirus were ''Effects of chloroquine on viral infections: an old drug against today's diseases?'' (2003), ''In vitro inhibition of severe acute respiratory syndrome coronavirus by chloroquine'' (2004), and ''New insights into the antiviral effects of chloroquine'' (2006).<ref name=c19study>[https://c19study.com/  C19 Study] by CovidAnalysis (accessed 31 July 2020)</ref>  Doctors familiar with medical research began prescribing hydroxychloroquine to combat SARS-CoV-2 because it was a less toxic alternative to chloroquine and the aforementioned studies meant that both drugs were treatment options worthy of serious consideration.  Two of the first countries to use HCQ were South Korea, who used hydroxychloroquine + zinc, and France, who used hydroxychloroquine + azithromycin. In the case of the USA, HCQ achieved prominence when [[Donald Trump]] promoted the drug as a treatment for COVID-19.  This view was inline with some of his political advisers such as [[Rudy Giuliani]], but certainly not all, Dr. Anthony Fauci being the principal skeptic.  In the case of [[Rudy Giuliani]], he conducted an interview with Dr. Vladimir Zelenko on his podcast ''Common Sense'' where Dr. Zelenko promoted the three drug regiment he was using to treat patients in New York - hydroxychloroquine (HCQ) + zinc + azithromycin (AZ).  This was a combination of the South Korean and French approaches to treating the disease.  Zelenko concluded that his treatment protocol was being effective based off of the results he was having treating his patients.<ref name=Zelenko1>[https://www.youtube.com/watch?v=1TJdjhd_XG8 EXCELLENT NEWS: Hydroxychloroquine Treatment Effective on 699 Patients] by Rudy Guiliani (Mar 28, 2020) ''Common Sense''</ref>   

More evidence supporting HCQ's effectiveness emerged as time progressed.  Didier Raoult, the French doctor whom administered HCQ + azithromycin, was having a mortality rate under .5% with patients showing up at the hospital.  Costa Rica, which began administering HCQ countrywide to treat patients, was having a lower case mortality rate when compared with the rest of the world.<ref name=DebunkHCQ>[https://www.youtube.com/watch?v=dLSYRqcg0wo&list=PLRgTUN1zz_oeQpnJxpeaEkFimDeepqyWf&index=35&t=520 Coranavirus: Debunking the Hydroxychloroquine Controversy] by Dr. Chris Martenson (April 22, 2020) ''Peak Prosperity''</ref>  Brazil, which began treating patients with hydroxychloroquine and azithromycin, studied their treatment protocol and determined that HCQ's benefit was highly statistically significant (p< 0.001).<ref name =Brazilstud>[https://www.freerepublic.com/focus/f-chat/3839186/posts Empirical treatment with hydroxychloroquine and azithromycin for suspected cases of COVID-19 followed-up by telemedicine] by Rodrigo Barbosa et al. (4/26/2020, 6:13:17 PM) NCT04348474</ref>  Spain was also having similar results (p=0.002).<ref name=Spainstud>[https://www.preprints.org/manuscript/202005.0057/v1 Early Hydroxychloroquine Is Associated with an Increase of Survival in COVID-19 Patients: An Observational Study] by Francisco Javier Membrillo de Novales et al. (2 May 2020) 2020050057</ref> Even [https://www.youtube.com/watch?v=uggOJcZBFoI&list=PLRgTUN1zz_oeQpnJxpeaEkFimDeepqyWf&index=15&t=1296 a Texas nursing home] had positive results using HCQ. None of these were double blind, randomized, placebo-controlled studies, but they were certainly enough evidence to suggest that a casual relationship between HCQ and COVID-19 recovery could be occurring, and that the relationship deserved to be researched further.

More evidence supporting HCQ's effectiveness emerged as time progressed.  Didier Raoult, the French doctor whom administered HCQ + azithromycin, was having a mortality rate under .5% with patients showing up at the hospital.  Costa Rica, which began administering HCQ countrywide to treat patients, was having a lower case mortality rate when compared with the rest of the world.<ref name=DebunkHCQ>[https://www.youtube.com/watch?v=dLSYRqcg0wo&list=PLRgTUN1zz_oeQpnJxpeaEkFimDeepqyWf&index=35&t=520 Coranavirus: Debunking the Hydroxychloroquine Controversy] by Dr. Chris Martenson (April 22, 2020) ''Peak Prosperity''</ref>  Brazil, which began treating patients with hydroxychloroquine and azithromycin, studied their treatment protocol and determined that HCQ's benefit was highly statistically significant (p< 0.001).<ref name =Brazilstud>[https://www.freerepublic.com/focus/f-chat/3839186/posts Empirical treatment with hydroxychloroquine and azithromycin for suspected cases of COVID-19 followed-up by telemedicine] by Rodrigo Barbosa et al. (4/26/2020, 6:13:17 PM) NCT04348474</ref>  Spain was also having similar results (p=0.002).<ref name=Spainstud>[https://www.preprints.org/manuscript/202005.0057/v1 Early Hydroxychloroquine Is Associated with an Increase of Survival in COVID-19 Patients: An Observational Study] by Francisco Javier Membrillo de Novales et al. (2 May 2020) 2020050057</ref> Even [https://www.youtube.com/watch?v=uggOJcZBFoI&list=PLRgTUN1zz_oeQpnJxpeaEkFimDeepqyWf&index=15&t=1296 a Texas nursing home] had positive results using HCQ. None of these were double blind, randomized, placebo-controlled studies, but they were certainly enough evidence to suggest that a casual relationship between HCQ and COVID-19 recovery could be occurring, and that the relationship deserved to be researched further.