*RINO Senator, [[Rob Portman]] is retiring. The Democrats have chosen [[Tim Ryan]] to be their candidate. The America First Candidate is [[J.D. Vance]].<ref>https://www.cincinnati.com/story/news/politics/2021/01/25/rob-portman-republican-ohio-senator-wont-run-re-election-2022/6696235002/</ref>
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*RINO Representative, [[Anthony Gonzalez]] is running for re-election. Trump has endorsed America First Candidate, [[Max Miller]] to take him down.<ref>https://www.politico.com/news/2021/02/22/trump-max-miller-ohio-470684</ref>
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===Democrats without Challengers===
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*[[Tim Ryan]] - Although he is retiring to run for senate, his seat can be flipped.
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===RINOs/Establishment Republicans without Challengers===