|Despite previously spending nearly $350,000 to defeat [[Dem]] incumbent [[Claire McCaskill]] before Akin won the Republican nomination, the Chamber of Commerce then refused to support Akin in the general election against McCaskill. | |Despite previously spending nearly $350,000 to defeat [[Dem]] incumbent [[Claire McCaskill]] before Akin won the Republican nomination, the Chamber of Commerce then refused to support Akin in the general election against McCaskill. |