Reece ran for Senate in 1948 to succeed retiring Democrat Tom Stewart, facing then U.S. Representative and future vice presidential nominee [[Estes Kefauver]]. He lost the general election in a landslide to Kefauver, mainly carrying counties in the eastern portion of the state.<ref>[https://www.ourcampaigns.com/RaceDetail.html?RaceID=89838 TN US Senate Race - Nov 02, 1948]. ''Our Campaigns''. Retrieved May 29, 2021.</ref>
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Reece ran for Senate in 1948 to succeed retiring Democrat Tom Stewart, facing then U.S. Representative and future vice presidential nominee [[Estes Kefauver|Carey Estes Kefauver]]. He lost the general election in a landslide to Kefauver, mainly carrying counties in the eastern portion of the state.<ref>[https://www.ourcampaigns.com/RaceDetail.html?RaceID=89838 TN US Senate Race - Nov 02, 1948]. ''Our Campaigns''. Retrieved May 29, 2021.</ref>