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#Laboratory experience from centuries of organic chemistry indicate that cross contamination of impure reactants and products in the natural world inhibit further formation of more complex biomolecules from simple ones, separation of necessary compounds generally does not occur in nature, any functional molecule that could even form would get terminated by the majority of nonfunctional material it emerged from, and self-organization is not a intrinsic property of biological matter.<ref name="NAS" />
#The '''water paradox''' is the chemical reality that water is essential for life and yet it destroys cellular components (e.g. proteins, enzymes and nucleic acids such as DNA and RNA).<ref name="water paradox" />
#Naturally, molecules never direct themselves towards life or even complex cellular machinery, they don't control when to start or stop synthesis, and do not preform purification processes to separate useful material from waste and byproducts.<ref name="Tour" />
#The problem of homochirality (see [[Chirality]])<ref>Sarfati, Jonathan, [http://creationontheweb.com/content/view/1719 Origin of life: the chirality problem], ''Journal of Creation'' 12(3):263–266, December 1998.</ref> refers to a fundamental puzzle in the origin of life, where essential biomolecules like amino acids and sugars are exclusively one "handedness" (enantiomer) in living cells (left handed amino acids [designated as "L-" such as in L-Lysine], and right handed sugars [designated as "D-" such as in D-glucose]). The problem is that laboratory experiments show that natural prebiotic chemistry produces equal amounts of both right and left handed forms (a racemic mixture) and this contaminates and inhibits any further synthesis, essentially killing synthesis of any useful molecules.<ref name="Tour" />
#Polymerization problem <ref>Sarfati, Jonathan, [http://creationontheweb.com/content/view/1791 Origin of life: the polymerization problem] ''Journal of Creation'' 12(3):281–284, December 1998.</ref>
